BIOPEP-UWM: Report

ID 2903
Name Precursor of neuropeptide
sequence
ANRSPSLRLRFG
Function:
Precursor of neuropeptide
 
Number of residues
12
Activity code
ne
Activity :
neuropeptide
Chemical mass 1373.5591 Monoisotopic mass 1372.7666
EC50 :
0.00 µM


Bibliographic data:
Authors
Veenstra J. A., Lambrou G.
Title
Isolation of a novel RFamide peptide from the midgut of the american cockroach, Periplaneta americana. Biochem. Biophys. Res. Commun., 213, 519-524, 1995
Year Source
1995 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@@](C)(N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CO)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C59H100N22O16/c1-30(2)23-37(51(92)73-35(16-10-20-69-58(64)65)49(90)78-39(47(88)71-27-45(85)86)25-33-13-7-6-8-14-33)76-48(89)34(15-9-19-68-57(62)63)72-52(93)38(24-31(3)4)77-54(95)41(28-82)79-55(96)43-18-12-22-81(43)56(97)42(29-83)80-50(91)36(17-11-21-70-59(66)67)74-53(94)40(26-44(61)84)75-46(87)32(5)60/h6-8,13-14,30-32,34-43,82-83H,9-12,15-29,60H2,1-5H3,(H2,61,84)(H,71,88)(H,72,93)(H,73,92)(H,74,94)(H,75,87)(H,76,89)(H,77,95)(H,78,90)(H,79,96)(H,80,91)(H,85,86)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70)/t32-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

InChIKey=AYLSSWGNHXBUMY-ZLWVBTNLSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2925 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: