BIOPEP-UWM: Report

ID 2904
Name Precursor of neuropeptide
sequence
GGRSPSLRLRFG
Function:
Precursor of neuropeptide
 
Number of residues
12
Activity code
ne
Activity :
neuropeptide
Chemical mass 1302.4814 Monoisotopic mass 1301.7296
EC50 :
0.00 µM


Bibliographic data:
Authors
Gaus G., Doble K. E., Price D. A., Greenburg M. J., Lee T. D., Battelle B.-A.
Title
The sequences of five neuropeptides isolated from Limulus using antisera to FMRFamide. Biol. Bull., 184, 322-329, 1993
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@@](CO)(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)CNC(=O)CN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C56H95N21O15/c1-30(2)22-36(49(88)71-35(16-10-20-66-56(62)63)48(87)74-38(45(84)68-27-44(82)83)24-32-12-6-5-7-13-32)72-47(86)34(15-9-19-65-55(60)61)70-50(89)37(23-31(3)4)73-51(90)39(28-78)75-52(91)41-17-11-21-77(41)53(92)40(29-79)76-46(85)33(14-8-18-64-54(58)59)69-43(81)26-67-42(80)25-57/h5-7,12-13,30-31,33-41,78-79H,8-11,14-29,57H2,1-4H3,(H,67,80)(H,68,84)(H,69,81)(H,70,89)(H,71,88)(H,72,86)(H,73,90)(H,74,87)(H,75,91)(H,76,85)(H,82,83)(H4,58,59,64)(H4,60,61,65)(H4,62,63,66)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1

InChIKey=GLHRFMWXNWTHQR-JBRKIFEHSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2921 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: