BIOPEP-UWM: Report

ID 2905
Name Precursor of neuropeptide
sequence
DRTPALRLRFG
Function:
Precursor of neuropeptide
 
Number of residues
11
Activity code
ne
Activity :
neuropeptide
Chemical mass 1301.4933 Monoisotopic mass 1300.7343
EC50 :
0.00 µM


Bibliographic data:
Authors
Sithigorngul P., Saraithongkum W., Jaideechoey S., Longyant S., Sithigorngul W.
Title
Novel FMRFamide-like neuropeptides from the eyestalk of the giant prawn Macrobrachium rosenbergii. Comp. Biochem. Physiol. B, 120, 587-595 (1998)
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C57H96N20O15/c1-29(2)24-38(73-45(83)31(5)69-53(91)41-19-13-23-77(41)54(92)44(32(6)78)76-50(88)37(18-12-22-67-57(63)64)70-46(84)34(58)27-42(79)80)51(89)71-35(16-10-20-65-55(59)60)48(86)74-39(25-30(3)4)52(90)72-36(17-11-21-66-56(61)62)49(87)75-40(47(85)68-28-43(81)82)26-33-14-8-7-9-15-33/h7-9,14-15,29-32,34-41,44,78H,10-13,16-28,58H2,1-6H3,(H,68,85)(H,69,91)(H,70,84)(H,71,89)(H,72,90)(H,73,83)(H,74,86)(H,75,87)(H,76,88)(H,79,80)(H,81,82)(H4,59,60,65)(H4,61,62,66)(H4,63,64,67)/t31-,32+,34-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1

InChIKey=VSOKWCKAKDENED-NBHIJXKISA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2924 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: