BIOPEP-UWM: Report

ID 2907
Name Precursor of neuropeptide
sequence
NYDKNFLRFG
Function:
Precursor of neuropeptide
 
Number of residues
10
Activity code
ne
Activity :
neuropeptide
Chemical mass 1273.3925 Monoisotopic mass 1272.6232
EC50 :
0.00 µM


Bibliographic data:
Authors
Sithigorngul P., Saraithongkum W., Jaideechoey S., Longyant S., Sithigorngul W.
Title
Novel FMRFamide-like neuropeptides from the eyestalk of the giant prawn Macrobrachium rosenbergii. Comp. Biochem. Physiol. B, 120, 587-595 (1998)
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C59H84N16O16/c1-32(2)24-40(54(87)69-39(17-11-23-66-59(64)65)53(86)72-41(51(84)67-31-49(81)82)25-33-12-5-3-6-13-33)71-56(89)43(26-34-14-7-4-8-15-34)73-57(90)44(29-47(63)78)74-52(85)38(16-9-10-22-60)68-58(91)45(30-48(79)80)75-55(88)42(27-35-18-20-36(76)21-19-35)70-50(83)37(61)28-46(62)77/h3-8,12-15,18-21,32,37-45,76H,9-11,16-17,22-31,60-61H2,1-2H3,(H2,62,77)(H2,63,78)(H,67,84)(H,68,91)(H,69,87)(H,70,83)(H,71,89)(H,72,86)(H,73,90)(H,74,85)(H,75,88)(H,79,80)(H,81,82)(H4,64,65,66)/t37-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1

InChIKey=VICKHFZPWYYFDT-NVAZTIMOSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2899 in the BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: