BIOPEP-UWM: Report

ID 2909
Name Precursor of neuropeptide
sequence
DRNFLRFG

Function:
Precursor of neuropeptide
 
Number of residues
8
Activity code
ne
Activity :
neuropeptide
Chemical mass 1024.1306 Monoisotopic mass 1023.5235
EC50 :
0.00 µM



Bibliographic data:
Authors
Mercier A. J., Orchard I., Tebrugge V., Skerrett M.
Title
Isolation of two FMRFamide-related peptides from crayfish pericardial organs. Peptides, 14, 137-143, 1993
Year Source
1993 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C46H69N15O12/c1-25(2)19-31(42(71)57-30(16-10-18-54-46(51)52)41(70)59-32(39(68)55-24-37(65)66)20-26-11-5-3-6-12-26)58-43(72)33(21-27-13-7-4-8-14-27)60-44(73)34(23-35(48)62)61-40(69)29(15-9-17-53-45(49)50)56-38(67)28(47)22-36(63)64/h3-8,11-14,25,28-34H,9-10,15-24,47H2,1-2H3,(H2,48,62)(H,55,68)(H,56,67)(H,57,71)(H,58,72)(H,59,70)(H,60,73)(H,61,69)(H,63,64)(H,65,66)(H4,49,50,53)(H4,51,52,54)/t28-,29-,30-,31-,32-,33-,34-/m0/s1

InChIKey=VDXRYTNIDUGNAW-NXBWRCJVSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2895 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456



Database reference: