BIOPEP-UWM: Report

ID 2916
Name Precursor of neuropeptide
sequence
TNRNFLRFG
Function:
Precursor of neuropeptide
 
Number of residues
9
Activity code
ne
Activity :
neuropeptide
Chemical mass 1124.2494 Monoisotopic mass 1123.5870
EC50 :
0.00 µM


Bibliographic data:
Authors
Trimmer B. A., Kobierski L. A., Kravitz E. A.
Title
Purification and characterization of FMRFamide-like immunoreactive substances from the lobster nervous system: Isolation and sequence analysis of two closely related peptides. J. Comp. Neurol., 266, 16-26, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(O)[C@]([H])(N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C50H77N17O13/c1-26(2)20-32(44(76)61-30(16-10-18-58-49(54)55)42(74)64-33(41(73)60-25-39(71)72)21-28-12-6-4-7-13-28)63-45(77)34(22-29-14-8-5-9-15-29)65-47(79)35(23-37(51)69)66-43(75)31(17-11-19-59-50(56)57)62-46(78)36(24-38(52)70)67-48(80)40(53)27(3)68/h4-9,12-15,26-27,30-36,40,68H,10-11,16-25,53H2,1-3H3,(H2,51,69)(H2,52,70)(H,60,73)(H,61,76)(H,62,78)(H,63,77)(H,64,74)(H,65,79)(H,66,75)(H,67,80)(H,71,72)(H4,54,55,58)(H4,56,57,59)/t27-,30+,31+,32+,33+,34+,35+,36+,40+/m1/s1

InChIKey=YIANXWRCHNLVPZ-VXZNJSSOSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2897 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: