BIOPEP-UWM: Report

ID 2917
Name Precursor of neuropeptide
sequence
SDRNFLRFG
Function:
Precursor of neuropeptide
 
Number of residues
9
Activity code
ne
Activity :
neuropeptide
Chemical mass 1111.2077 Monoisotopic mass 1110.5554
EC50 :
0.00 µM


Bibliographic data:
Authors
Trimmer B. A., Kobierski L. A., Kravitz E. A.
Title
Purification and characterization of FMRFamide-like immunoreactive substances from the lobster nervous system: Isolation and sequence analysis of two closely related peptides. J. Comp. Neurol., 266, 16-26, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@](N)(CO)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C49H74N16O14/c1-26(2)19-32(44(76)59-30(15-9-17-56-48(52)53)42(74)63-33(41(73)58-24-39(70)71)20-27-11-5-3-6-12-27)62-45(77)34(21-28-13-7-4-8-14-28)64-46(78)35(22-37(51)67)65-43(75)31(16-10-18-57-49(54)55)60-47(79)36(23-38(68)69)61-40(72)29(50)25-66/h3-8,11-14,26,29-36,66H,9-10,15-25,50H2,1-2H3,(H2,51,67)(H,58,73)(H,59,76)(H,60,79)(H,61,72)(H,62,77)(H,63,74)(H,64,78)(H,65,75)(H,68,69)(H,70,71)(H4,52,53,56)(H4,54,55,57)/t29-,30-,31-,32-,33-,34-,35-,36-/m0/s1

InChIKey=CWANIQQRPSLCSW-VTGDPKQBSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of neuropeptide (ID 2911 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: