BIOPEP-UWM: Report

ID 2948
Name Mellitin from venom of honey bee (Apis mellifera)
sequence
GIGAVLKVLTTGLPALISWIKRKRQQ~
Function:
Antibacterial
 
Number of residues
26
Activity code
ab
Activity :
antibacterial
Chemical mass 2846.4535 Monoisotopic mass 2844.7490
EC50 :
0.00 µM


Bibliographic data:
Authors
Fennell J. F., Shipman W. H., Cole L. J.
Title
Antibacterial action of a bee venom fraction (melittin) against a penicillin-resistant staphylococcus and other microorganisms. USNRDL-TR-67-101. Res. Dev. Tech. Rep., Dec 5, 1-13, 1967
Year Source
1967 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
[H][C@@](C)(NC(=O)CNC(=O)[C@@]([H])(NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(N)=O

InChI=1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1

InChIKey=VDXZNPDIRNWWCW-JFTDCZMZSA-N


Active against G(+) and G(-) bacteria


Antiangiogenic peptide according to the ChEMBL database
Anticancer peptide according to the CancerPPD database; the ChEMBL database
Cytotoxic peptide according to the ChEMBL database
Hemolytic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2948); the ChEMBL database; the Hemolytik database; the PubChem database
Antiviral peptide according to the AVPdb database; the ChEMBL database; the HIPdb database; the PubChem database
Antifungal peptide according to the ChEMBL database


Database reference:
APD: ID AP00146

AVPdb: ID AVP1240

BIOPEP-UWM database of bioactive peptides: ID 2949

BRENDA: Ligand Bee venom melittin

CAMP: ID CAMPSQ1142; CAMPSQ6421; CAMPSQ6424; CAMPSQ6425

CancerPPD: ID 1841; 1993; 2145; 2297; 2450; 2593; 2736; 3337; 3338; 3339; 3340; 3791; 3797; 3803; 3809; 3815; 5011

ChEBI: ID 6736

ChEMBL: ID CHEMBL412927

ChemIDplus: ID 37231-28-0

ChemSpider: ID 17290230

ECHA: ID 253-417-7

EROP-Moscow: ID E01940

Hemolytik: ID 1076; 1692; 1693; 1722; 2354; 2441; 2472; 2700; 2701; 2770; 3294; 3295; 3296; 3297; 3581; 3582; 3583

HIPdb: ID HIP960

Metabolights: ID MTBLC6736

Neuropep: ID NP03142

NIAID: ID 227100

Parapep: ID 1339; 1409; 1455

PeptideDB: ID PEP06635; PEP07065; PEP07066; PEP16532

PubChem: CID 16133648

SATPdb: ID satpdb13084; satpdb26713