BIOPEP-UWM: Report

ID 2954
Name Precursor of mastoparan
sequence
INLKALAALAKKILG
Function:
Precursor of hemolytic peptide
 
Number of residues
15
Activity code
he
Activity :
haemolytic
Chemical mass 1536.9382 Monoisotopic mass 1536.0096
EC50 :
0.00 µM


Bibliographic data:
Authors
Moerman L., Bosteels S., Noppe W., Willems J., Clynen E., Schoofs L., Thevissen K., Tytgat J., Van Eldere J., Van Der Walt J., Verdonck F.
Title
Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. Eur. J. Biochem., 269, 4799-4810, 2002
Year Source
2002 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)O

InChI=1S/C72H133N19O17/c1-17-41(11)57(77)71(107)89-54(35-55(76)92)70(106)88-53(34-40(9)10)69(105)85-47(25-19-22-28-73)64(100)80-46(16)62(98)87-51(32-38(5)6)67(103)81-43(13)59(95)79-44(14)61(97)86-52(33-39(7)8)68(104)82-45(15)60(96)83-48(26-20-23-29-74)65(101)84-49(27-21-24-30-75)66(102)91-58(42(12)18-2)72(108)90-50(31-37(3)4)63(99)78-36-56(93)94/h37-54,57-58H,17-36,73-75,77H2,1-16H3,(H2,76,92)(H,78,99)(H,79,95)(H,80,100)(H,81,103)(H,82,104)(H,83,96)(H,84,101)(H,85,105)(H,86,97)(H,87,98)(H,88,106)(H,89,107)(H,90,108)(H,91,102)(H,93,94)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,57-,58-/m0/s1

InChIKey=PRERRIQWXGZVIX-XFTSROOISA-N



The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of hemolytic peptide (ID 2953 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: