BIOPEP-UWM: Report

ID 2964
Name Precursor of antibacterial peptide
sequence
GLLQTIKEKLESLESLAKGIVSGIQAG
Function:
Precursor of antibacterial peptide
 
Number of residues
27
Activity code
ab
Activity :
antibacterial
Chemical mass 2783.2129 Monoisotopic mass 2781.5800
EC50 :
0.00 µM


Bibliographic data:
Authors
Rozek T., Waugh R. J., Steinborner S. T., Bowie J. H., Tyler M. J., Wallace J. C.
Title
The Maculatin peptides from the skin glands of the tree frog Litoria genimaculata: a comparison of the structures and antibacterial activities of Maculatin 1.1 and Caerin 1.1. J. Pept. Sci. 4, 111-115, 1998
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)O

InChI=1S/C123H216N32O40/c1-22-65(16)97(120(192)143-74(34-39-87(128)160)105(177)133-68(19)101(173)132-55-95(171)172)151-91(164)54-131-104(176)84(56-156)150-119(191)96(64(14)15)153-122(194)98(66(17)23-2)152-90(163)53-130-103(175)71(31-25-28-44-124)136-102(174)69(20)134-112(184)80(48-60(6)7)146-117(189)85(57-157)148-110(182)78(38-43-94(169)170)141-116(188)83(51-63(12)13)147-118(190)86(58-158)149-109(181)77(37-42-93(167)168)140-114(186)81(49-61(8)9)144-107(179)72(32-26-29-45-125)137-108(180)76(36-41-92(165)166)138-106(178)73(33-27-30-46-126)142-121(193)99(67(18)24-3)154-123(195)100(70(21)159)155-111(183)75(35-40-88(129)161)139-115(187)82(50-62(10)11)145-113(185)79(47-59(4)5)135-89(162)52-127/h59-86,96-100,156-159H,22-58,124-127H2,1-21H3,(H2,128,160)(H2,129,161)(H,130,175)(H,131,176)(H,132,173)(H,133,177)(H,134,184)(H,135,162)(H,136,174)(H,137,180)(H,138,178)(H,139,187)(H,140,186)(H,141,188)(H,142,193)(H,143,192)(H,144,179)(H,145,185)(H,146,189)(H,147,190)(H,148,182)(H,149,181)(H,150,191)(H,151,164)(H,152,163)(H,153,194)(H,154,195)(H,155,183)(H,165,166)(H,167,168)(H,169,170)(H,171,172)/t65-,66-,67-,68-,69-,70+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,96-,97-,98-,99-,100-/m0/s1

InChIKey=BGKFRSGBSASAJH-QTDZWGBRSA-N


The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antibacterial peptide (ID 2963 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: