BIOPEP-UWM: Report

ID 2969
Name Precursor of antibacterial peptide
sequence
FVGLAKVAAHVVPAIAEHFG
Function:
Precursor of antibacterial peptide
 
Number of residues
20
Activity code
ab
Activity :
antibacterial
Chemical mass 2033.3687 Monoisotopic mass 2032.1224
EC50 :
0.00 µM


Bibliographic data:
Authors
Chia B. C., Carver J. A., Mulhern T. D., Bowie J. H.
Title
Maculatin 1.1, an anti-microbial peptide from the Australian tree frog, Litoria genimaculata solution structure and biological activity. Eur. J. Biochem., 267, 1894-1908, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(=O)O

InChI=1S/C97H149N25O23/c1-18-54(12)79(96(144)110-58(16)82(130)113-66(34-35-73(124)125)87(135)116-69(41-62-43-100-47-104-62)90(138)115-68(86(134)103-46-74(126)127)40-61-30-23-20-24-31-61)121-84(132)59(17)108-92(140)71-33-27-37-122(71)97(145)78(53(10)11)120-95(143)77(52(8)9)119-91(139)70(42-63-44-101-48-105-63)114-83(131)56(14)106-80(128)55(13)109-94(142)76(51(6)7)118-88(136)65(32-25-26-36-98)112-81(129)57(15)107-89(137)67(38-49(2)3)111-72(123)45-102-93(141)75(50(4)5)117-85(133)64(99)39-60-28-21-19-22-29-60/h19-24,28-31,43-44,47-59,64-71,75-79H,18,25-27,32-42,45-46,98-99H2,1-17H3,(H,100,104)(H,101,105)(H,102,141)(H,103,134)(H,106,128)(H,107,137)(H,108,140)(H,109,142)(H,110,144)(H,111,123)(H,112,129)(H,113,130)(H,114,131)(H,115,138)(H,116,135)(H,117,133)(H,118,136)(H,119,139)(H,120,143)(H,121,132)(H,124,125)(H,126,127)/t54-,55-,56-,57-,58-,59-,64-,65-,66-,67-,68-,69-,70-,71-,75-,76-,77-,78-,79-/m0/s1

InChIKey= BCRPSEOFFXEGAZ-GFYMVKNFSA-N


The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antibacterial peptide (ID 2970 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: