BIOPEP-UWM: Report

ID 2971
Name Precursor of antibacterial peptide
sequence
GLFGVLAKVAAHVVPAIAEHFG
Function:
Precursor of antibacterial peptide
 
Number of residues
22
Activity code
ab
Activity :
antibacterial
Chemical mass 2203.5771 Monoisotopic mass 2202.2276
EC50 :
0.00 µM


Bibliographic data:
Authors
Wegener K. L., Wabnitz P. A., Carver J. A., Bowie J. H., Chia B. C., Wallace J. C., Tyler M. J.
Title
Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1. Eur. J. Biochem., 265, 627-637, 1999
Year Source
1999 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES:
[H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CC(C)C)NC(=O)CN)C(C)C)C(C)C)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C105H163N27O25/c1-20-59(14)86(104(156)118-63(18)89(141)121-70(36-37-80(135)136)94(146)125-75(44-67-47-108-51-112-67)98(150)124-74(93(145)111-50-81(137)138)43-66-32-25-22-26-33-66)131-91(143)64(19)116-100(152)77-35-29-39-132(77)105(157)85(58(12)13)130-103(155)84(57(10)11)129-99(151)76(45-68-48-109-52-113-68)122-90(142)61(16)114-87(139)60(15)117-101(153)83(56(8)9)128-95(147)69(34-27-28-38-106)120-88(140)62(17)115-96(148)72(41-54(4)5)126-102(154)82(55(6)7)127-79(134)49-110-92(144)73(42-65-30-23-21-24-31-65)123-97(149)71(40-53(2)3)119-78(133)46-107/h21-26,30-33,47-48,51-64,69-77,82-86H,20,27-29,34-46,49-50,106-107H2,1-19H3,(H,108,112)(H,109,113)(H,110,144)(H,111,145)(H,114,139)(H,115,148)(H,116,152)(H,117,153)(H,118,156)(H,119,133)(H,120,140)(H,121,141)(H,122,142)(H,123,149)(H,124,150)(H,125,146)(H,126,154)(H,127,134)(H,128,147)(H,129,151)(H,130,155)(H,131,143)(H,135,136)(H,137,138)/t59-,60-,61-,62-,63-,64-,69-,70-,71-,72-,73-,74-,75-,76-,77-,82-,83-,84-,85-,86-/m0/s1

InChIKey=BVSZUIMUKLEYDN-VGXFQSQPSA-N


The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antibacterial peptide (ID 2972 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: