BIOPEP-UWM: Report

ID 2973
Name LVV-hemorphin-7
sequence
LVVYPWTQRF
Function:
opioid agonist
 
Number of residues
10
Activity code
op
Activity :
opioid
Chemical mass 1308.5223 Monoisotopic mass 1307.7005
EC50 :
29.10 µM


Bibliographic data:
Authors
Glamsta E.-L., Meyerson B., Silberring J., Terenius L., Nyberg F.
Title
Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings. Biochem. Biophys. Res. Commun., 184, 1060-1066, 1992
Year Source
1992 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES:
[H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O

InChI=1S/C65H93N15O14/c1-34(2)29-43(66)55(84)77-53(36(5)6)61(90)78-52(35(3)4)60(89)75-48(30-39-21-23-41(82)24-22-39)63(92)80-28-14-20-50(80)59(88)74-47(32-40-33-71-44-18-12-11-17-42(40)44)58(87)79-54(37(7)81)62(91)73-46(25-26-51(67)83)57(86)72-45(19-13-27-70-65(68)69)56(85)76-49(64(93)94)31-38-15-9-8-10-16-38/h8-12,15-18,21-24,33-37,43,45-50,52-54,71,81-82H,13-14,19-20,25-32,66H2,1-7H3,(H2,67,83)(H,72,86)(H,73,91)(H,74,88)(H,75,89)(H,76,85)(H,77,84)(H,78,90)(H,79,87)(H,93,94)(H4,68,69,70)/t37-,43+,45+,46+,47+,48+,49+,50+,52+,53+,54+/m1/s1

InChIKey=NBQSSMDPPLHNDC-GSOGOTFGSA-N


Obtained also from bovine hemoglobin

Piot J.-M., Zhao Q., Guillochon D., Ricart G., Thomas D., 1992, Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysate. Biochem. Biophys. Res. Commun., 189, 101-110;

Di Bernardini R., Rai D. K., Bolton D., Kerry J., O’Neill E., Mullen A. M., Harnedy P., Hayes M., 2011, Isolation, purification and characterization of antioxidant peptidic fractions from a bovien liver sarcoplasmic protein thermolysin hydrolysate. Peptides, 32, 388-400

Inhibitor of Membrane alanyl aminopeptidase (EC 3.4.11.2) (MEROPS ID: M01.001) according to the BRENDA database
Inhibitor of Cystinyl aminopeptidase (EC 3.4.11.3) (MEROPS ID: M01.011) according to the BRENDA database
Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9474); the BRENDA database


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9474

BRENDA: Ligand LVV-hemorphin 7

ChemIDplus: ID 75808-66-1

ChemSpider: ID 112434

EROP-Moscow: ID E00290

J-GLOBAL: ID 200907048762870536

Nikkaji: ID J603.199D

PepBank: peptide LVVYPWTQRF

PeptideDB: ID PEP07091

PubChem: CID 126532