BIOPEP-UWM: Report

ID 2974
Name LVV-hemorphin-5
sequence
LVVYPWTQ
Function:
Opioid
 
Number of residues
8
Activity code
op
Activity :
opioid
Chemical mass 1005.1636 Monoisotopic mass 1004.5314
EC50 :
80.50 µM


Bibliographic data:
Authors
Zhao Q., Piot J. M.
Title
Investigation of inhibition angiotensin-converting enzyme (ACE) activity and opioid activity of two hemorphins, LVV-hemorphin-5 and VV-hemorphin-5, isolated from a defined peptic hydrolysate of bovine hemoglobin. Neuropeptides, 31, 147-153, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O.N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N7[C@@H](CCC7)C(=O)N[C@@H](CC8=C[N]([H])C9=CC=CC=C89)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O

InChI=1S/C65H93N15O14.C50H72N10O12/c1-34(2)29-43(66)55(84)77-53(36(5)6)61(90)78-52(35(3)4)60(89)75-48(30-39-21-23-41(82)24-22-39)63(92)80-28-14-20-50(80)59(88)74-47(32-40-33-71-44-18-12-11-17-42(40)44)58(87)79-54(37(7)81)62(91)73-46(25-26-51(67)83)57(86)72-45(19-13-27-70-65(68)69)56(85)76-49(64(93)94)31-38-15-9-8-10-16-38;1-25(2)21-33(51)43(64)57-41(27(5)6)47(68)58-40(26(3)4)46(67)56-37(22-29-14-16-31(62)17-15-29)49(70)60-20-10-13-38(60)45(66)55-36(23-30-24-53-34-12-9-8-11-32(30)34)44(65)59-42(28(7)61)48(69)54-35(50(71)72)18-19-39(52)63/h8-12,15-18,21-24,33-37,43,45-50,52-54,71,81-82H,13-14,19-20,25-32,66H2,1-7H3,(H2,67,83)(H,72,86)(H,73,91)(H,74,88)(H,75,89)(H,76,85)(H,77,84)(H,78,90)(H,79,87)(H,93,94)(H4,68,69,70);8-9,11-12,14-17,24-28,33,35-38,40-42,53,61-62H,10,13,18-23,51H2,1-7H3,(H2,52,63)(H,54,69)(H,55,66)(H,56,67)(H,57,64)(H,58,68)(H,59,65)(H,71,72)/t37-,43+,45+,46+,47+,48+,49+,50+,52+,53+,54+;28-,33+,35+,36+,37+,38+,40+,41+,42+/m11/s1

InChIKey: VGPAXAQBONOOQM-XSYCEYQRSA-N


First reference concerning peptide:
Karelin A. A., Philippova M. M., Karelina E. V.,Ivanov V. T., 1994, Isolation of endogenous hemorphin-related hemoglobin fragments from bovine brain. Biochem. Biophys. Res. Commun., 202, 410-415


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9278)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 9278

EROP-Moscow: ID E01090