BIOPEP-UWM: Report

ID 2999
Name CaMKII inhibitor
sequence
AKALRRQEAVDAL
Function:
Inhibitor of Ca2+/calmodulin-dependent protein kinase (EC 2.7.11.17)
 
Number of residues
13
Activity code
cmk2
Activity :
CaMKII Inhibitor
Chemical mass 1440.6431 Monoisotopic mass 1439.8184
EC50 :
0.24 µM


Bibliographic data:
Authors
Ishida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.
Title
Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett., 427, 115-118
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(O)=O

InChI=1S/C61H109N21O19/c1-28(2)25-40(79-48(89)32(8)71-51(92)35(15-11-12-22-62)74-47(88)31(7)63)57(98)76-37(17-14-24-70-61(67)68)53(94)75-36(16-13-23-69-60(65)66)54(95)77-38(18-20-43(64)83)55(96)78-39(19-21-44(84)85)52(93)72-34(10)50(91)82-46(30(5)6)58(99)80-41(27-45(86)87)56(97)73-33(9)49(90)81-42(59(100)101)26-29(3)4/h28-42,46H,11-27,62-63H2,1-10H3,(H2,64,83)(H,71,92)(H,72,93)(H,73,97)(H,74,88)(H,75,94)(H,76,98)(H,77,95)(H,78,96)(H,79,89)(H,80,99)(H,81,90)(H,82,91)(H,84,85)(H,86,87)(H,100,101)(H4,65,66,69)(H4,67,68,70)/t31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1

InChIKey=QEIKZDQWLVXETG-ZBGBXVNVSA-N


Database reference: