BIOPEP-UWM: Report

ID 3033
Name CaMPDE inhibitor
sequence
VYQHQKAMKPWIQPKTKVIPYVRY
Function:
Inhibitor of 3′,5′-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17), another name calmodulin-dependent phosphodiesterase 1 (abbrev. CaMPDE)
 
Number of residues
24
Activity code
35pd
Activity :
CaMPDE inhibitor
Chemical mass 3002.5708 Monoisotopic mass 3000.6474
EC50 :
0.00 µM


Bibliographic data:
Authors
Kizawa A., Nagamura K., Murakami U.
Title
Calmodulin-binding peptides isolated from alpha-casein peptone. J. Dairy Res., 62, 587-592, 1995
Year Source
1995 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(CC1=CN=CN1)NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O

InChI=1S/C143H221N37O32S/c1-14-79(9)116(175-130(199)104(71-86-73-156-92-31-17-16-30-91(86)92)170-132(201)108-38-28-64-178(108)139(208)100(35-21-25-62-147)166-124(193)99(58-67-213-13)159-119(188)81(11)158-120(189)93(32-18-22-59-144)160-122(191)97(52-55-110(148)185)162-128(197)105(72-87-74-154-75-157-87)168-123(192)98(53-56-111(149)186)161-127(196)102(171-134(203)113(151)76(3)4)68-83-40-46-88(182)47-41-83)137(206)167-101(54-57-112(150)187)140(209)179-65-27-37-107(179)131(200)163-94(33-19-23-60-145)126(195)177-118(82(12)181)138(207)165-95(34-20-24-61-146)125(194)173-115(78(7)8)136(205)176-117(80(10)15-2)141(210)180-66-29-39-109(180)133(202)169-103(69-84-42-48-89(183)49-43-84)129(198)174-114(77(5)6)135(204)164-96(36-26-63-155-143(152)153)121(190)172-106(142(211)212)70-85-44-50-90(184)51-45-85/h16-17,30-31,40-51,73-82,93-109,113-118,156,181-184H,14-15,18-29,32-39,52-72,144-147,151H2,1-13H3,(H2,148,185)(H2,149,186)(H2,150,187)(H,154,157)(H,158,189)(H,159,188)(H,160,191)(H,161,196)(H,162,197)(H,163,200)(H,164,204)(H,165,207)(H,166,193)(H,167,206)(H,168,192)(H,169,202)(H,170,201)(H,171,203)(H,172,190)(H,173,194)(H,174,198)(H,175,199)(H,176,205)(H,177,195)(H,211,212)(H4,152,153,155)/t79-,80-,81-,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,113-,114-,115-,116-,117-,118-/m0/s1

InChIKey=SEGAZYKLYHBEOE-KLUNNKHRSA-N


Mode of action: calmodulin binding


Database reference: