BIOPEP-UWM: Report

ID 3035
Name isracidin
sequence
RPKHPIKHQGLPQEVLNENLLRF
Function:
Antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Listeria monocytogenes and lactobacilli
 
Number of residues
23
Activity code
ab
Activity :
antibacterial
Chemical mass 2764.1833 Monoisotopic mass 2762.5411
EC50 :
0.00 µM


Bibliographic data:
Authors
Lahov E., Regelson W.
Title
Antibacterial and immunostimulating casein-derived substances from milk:casecidin, isracidin peptides. Food Chem. Toxicol., 34(1), 131-145 (1996)
Year Source
1996 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O

InChI=1S/C125H203N39O32/c1-13-69(12)101(161-117(189)92-34-25-49-164(92)122(194)88(56-72-60-138-63-143-72)158-104(176)74(29-17-19-43-126)149-115(187)90-32-23-47-162(90)120(192)73(128)28-21-45-139-124(133)134)119(191)151-75(30-18-20-44-127)103(175)154-84(55-71-59-137-62-142-71)112(184)146-77(35-39-93(129)165)102(174)141-61-97(169)144-87(53-67(8)9)121(193)163-48-24-33-91(163)116(188)150-78(36-40-94(130)166)106(178)147-80(38-42-99(172)173)108(180)160-100(68(10)11)118(190)157-83(52-66(6)7)111(183)156-85(57-95(131)167)113(185)148-79(37-41-98(170)171)107(179)155-86(58-96(132)168)114(186)153-82(51-65(4)5)110(182)152-81(50-64(2)3)109(181)145-76(31-22-46-140-125(135)136)105(177)159-89(123(195)196)54-70-26-15-14-16-27-70/h14-16,26-27,59-60,62-69,73-92,100-101H,13,17-25,28-58,61,126-128H2,1-12H3,(H2,129,165)(H2,130,166)(H2,131,167)(H2,132,168)(H,137,142)(H,138,143)(H,141,174)(H,144,169)(H,145,181)(H,146,184)(H,147,178)(H,148,185)(H,149,187)(H,150,188)(H,151,191)(H,152,182)(H,153,186)(H,154,175)(H,155,179)(H,156,183)(H,157,190)(H,158,176)(H,159,177)(H,160,180)(H,161,189)(H,170,171)(H,172,173)(H,195,196)(H4,133,134,139)(H4,135,136,140)/t69-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,100-,101-/m0/s1

InChIKey=POPBCYBNIJKVES-XAFWQQJMSA-N


Cationic and hydrophobic peptide. Peptide obtained by hydrolysis of bovine alphaS1-casein by use of chymosin. Fragment (1-23).


Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8171)
Antiviral peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9530); the DBAASP database; the HIPdb database; the PubChem database
Cytotoxic peptide according to the DBAASP database; the PubChem database


Database reference:
APD: ID AP01400

BIOPEP-UWM database of bioactive peptides: ID 8171; 9530

CAMP: ID CAMPSQ3215

ChEMBL: ID CHEMBL1240735

ChemSpider: ID 17338406

DBAASP: ID 2307

EROP-Moscow: ID E14691

HIPdb: ID HIP748

MBPDB: Peptide RPKHPIKHQGLPQEVLNENLLRF

MilkAMP: ID CAA0001; CAA0002

NIAID: ID 502750

PubChem: CID: 16210274

SATPdb: ID satpdb26618