BIOPEP-UWM: Report

ID 3053
Name Indolicidin
sequence
ILPWKWPWWPWRR~
Function:
Antibacterial
 
Number of residues
13
Activity code
ab
Activity :
antibacterial
Chemical mass 1906.2792 Monoisotopic mass 1905.0439
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Novotny M. J ., Morris W. L., Tang Y.-Q., Smith W., Cullor J. S.
Title
Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 267, 4292-4295, 1992
Year Source
1992 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(N)=O

InChI=1S/C100H132N26O13/c1-5-57(4)85(102)95(136)123-79(45-56(2)3)96(137)124-42-20-36-82(124)92(133)118-76(46-58-51-110-68-28-11-6-23-63(58)68)89(130)116-74(33-16-17-39-101)88(129)121-80(49-61-54-113-71-31-14-9-26-66(61)71)97(138)125-43-21-38-84(125)94(135)120-78(48-60-53-112-70-30-13-8-25-65(60)70)91(132)122-81(50-62-55-114-72-32-15-10-27-67(62)72)98(139)126-44-22-37-83(126)93(134)119-77(47-59-52-111-69-29-12-7-24-64(59)69)90(131)117-75(35-19-41-109-100(106)107)87(128)115-73(86(103)127)34-18-40-108-99(104)105/h6-15,23-32,51-57,73-85,110-114H,5,16-22,33-50,101-102H2,1-4H3,(H2,103,127)(H,115,128)(H,116,130)(H,117,131)(H,118,133)(H,119,134)(H,120,135)(H,121,129)(H,122,132)(H,123,136)(H4,104,105,108)(H4,106,107,109)/t57-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-/m0/s1

InChIKey=USSYUMHVHQSYNA-SLDJZXPVSA-N


The active form of this peptide is C-terminal amide. Indolicidin is active against G(-) bacteria. BBA, 1197, 109-131 (1994).

Antiviral peptide according to the BindingDB database; DBAASP database; the EROP-Moscow database
Hemolytic peptide according to the Hemolytik database
Anticancer peptide according to the CancerPPD database


Database reference:
APD: ID AP00150

BindingDB: ID 50155348

CancerPPD: ID 1812; 1964; 2116; 2268; 2420; 2563; 2706

ChEMBL: ID CHEMBL415216

ChemSpider: ID 17286525

DBAASP: ID 491

EPA DSSTox: ID DTXSID2040866

EROP-Moscow: ID E01472

Hemolytik: ID 1038; 1450; 1470; 1495; 1719; 2212; 2449; 3026; 3030; 3034; 3038; 3655; 3656; 3657; 3947

HIPdb: ID HIP1059

J-GLOBAL: ID 200907028214014329

Nikkaji: ID J652.745K

ParaPep: ID 1301; 1302

PepBank: Peptide ILPWKWPWWPWRR

PeptideDB: ID PEP05562

PubChem: CID 16129733

SATPdb: ID satpdb10356; satpdb22480