BIOPEP-UWM: Report

ID 3070
Name human defensin HNP-4
sequence
VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
Function:
antibacterial
 
Number of residues
33
Activity code
ab
Activity :
antibacterial
Chemical mass 3715.4409 Monoisotopic mass 3712.8010
EC50 :
0.00 µM


Bibliographic data:
Authors
Wilde C. G., Griffith J. E., Marra M. N., Snable J. L., Scott R. W.
Title
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J. Biol. Chem., 264, 11200-11203, 1989
Year Source
1989 Journal


Additional information:
SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(O)=O

InChI=1S/C157H261N49O43S6/c1-22-80(18)119(146(242)176-61-110(214)175-62-112(216)199-116(77(12)13)147(243)192-102(65-208)136(232)188-99(58-85-36-27-24-28-37-85)135(231)205-122(83(21)211)151(247)190-98(59-86-43-45-87(212)46-44-86)131(227)194-106(69-253)142(238)197-108(71-255)143(239)206-121(82(20)210)149(245)183-92(42-33-53-174-157(168)169)127(223)202-118(79(16)17)152(248)249)203-134(230)96(56-74(6)7)187-140(236)105(68-252)195-132(228)100(60-109(158)213)178-111(215)63-177-145(241)115(76(10)11)200-126(222)90(40-31-51-172-155(164)165)180-129(225)94(54-72(2)3)185-125(221)93(47-48-113(217)218)184-150(246)120(81(19)209)204-128(224)91(41-32-52-173-156(166)167)179-123(219)88(38-29-49-170-153(160)161)181-138(234)103(66-250)193-130(226)97(57-84-34-25-23-26-35-84)189-148(244)117(78(14)15)201-133(229)95(55-73(4)5)186-124(220)89(39-30-50-171-154(162)163)182-139(235)104(67-251)196-137(233)101(64-207)191-141(237)107(70-254)198-144(240)114(159)75(8)9/h23-28,34-37,43-46,72-83,88-108,114-122,207-212,250-255H,22,29-33,38-42,47-71,159H2,1-21H3,(H2,158,213)(H,175,214)(H,176,242)(H,177,241)(H,178,215)(H,179,219)(H,180,225)(H,181,234)(H,182,235)(H,183,245)(H,184,246)(H,185,221)(H,186,220)(H,187,236)(H,188,232)(H,189,244)(H,190,247)(H,191,237)(H,192,243)(H,193,226)(H,194,227)(H,195,228)(H,196,233)(H,197,238)(H,198,240)(H,199,216)(H,200,222)(H,201,229)(H,202,223)(H,203,230)(H,204,224)(H,205,231)(H,206,239)(H,217,218)(H,248,249)(H4,160,161,170)(H4,162,163,171)(H4,164,165,172)(H4,166,167,173)(H4,168,169,174)/t80-,81+,82+,83+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-,118-,119-,120-,121-,122-/m0/s1

InChIKey=XVMPVABBHYGIBV-QBHMEAHGSA-N


Disulfide bonds: C2-C30; C4-C19; C9-C29 according to the DBAASP database; the PeptideDB database

Antiviral peptide according to the APD database; the DBAASP database
Antifungal peptide according to the APD database; the CAMP database
Inhibitor of corticosterone production according to the EROP-Moscow database


Database reference:
APD: ID AP00179

CAMP: ID CAMPSQ396

ChemSpider: ID 17295241

DBAASP: ID 1648

EROP-Moscow: ID E01250

PeptideDB: ID PEP04436

PubChem: CID 16138735

RSCB PDB: ID1ZMM

SATPdb: ID satpdb13579