BIOPEP-UWM: Report

ID 3071
Name human defensin HNP-3
sequence
DCYCRIPACIAGERRYGTCIYQGRLWAFCC
Function:
antibacterial
 
Number of residues
30
Activity code
ab
Activity :
antibacterial
Chemical mass 3492.0843 Monoisotopic mass 3489.5434
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Harwig S. S., Ganz T., Schilling J. W., Lehrer R. I.
Title
Primary structures of three human neutrophil defensins. J. Clin. Invest., 76, 1436-1439, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [C@H](N)(CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=C[N]C6=C5C=CC=C6)C(=O)N[C@@H](C)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(O)=O

InChI=1S/C151H228N44O40S6/c1-13-74(6)117(192-140(227)107(70-239)185-123(210)79(11)171-142(229)110-34-25-55-195(110)146(233)119(76(8)15-3)194-131(218)95(33-24-54-165-151(160)161)177-137(224)105(68-237)187-136(223)101(59-83-37-43-87(198)44-38-83)182-138(225)104(67-236)186-124(211)90(152)62-116(206)207)143(230)172-77(9)121(208)167-64-112(201)174-97(48-50-115(204)205)130(217)176-93(31-22-52-163-149(156)157)128(215)175-94(32-23-53-164-150(158)159)129(216)181-99(58-82-35-41-86(197)42-36-82)126(213)169-66-114(203)191-120(80(12)196)145(232)189-108(71-240)141(228)193-118(75(7)14-2)144(231)184-102(60-84-39-45-88(199)46-40-84)134(221)178-96(47-49-111(153)200)125(212)168-65-113(202)173-92(30-21-51-162-148(154)155)127(214)180-98(56-73(4)5)133(220)183-103(61-85-63-166-91-29-20-19-28-89(85)91)132(219)170-78(10)122(209)179-100(57-81-26-17-16-18-27-81)135(222)188-106(69-238)139(226)190-109(72-241)147(234)235/h16-20,26-29,35-46,63,73-80,90,92-110,117-120,166,196-199,236-241H,13-15,21-25,30-34,47-62,64-72,152H2,1-12H3,(H2,153,200)(H,167,208)(H,168,212)(H,169,213)(H,170,219)(H,171,229)(H,172,230)(H,173,202)(H,174,201)(H,175,215)(H,176,217)(H,177,224)(H,178,221)(H,179,209)(H,180,214)(H,181,216)(H,182,225)(H,183,220)(H,184,231)(H,185,210)(H,186,211)(H,187,223)(H,188,222)(H,189,232)(H,190,226)(H,191,203)(H,192,227)(H,193,228)(H,194,218)(H,204,205)(H,206,207)(H,234,235)(H4,154,155,162)(H4,156,157,163)(H4,158,159,164)(H4,160,161,165)/t74-,75-,76-,77-,78-,79-,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,117-,118-,119-,120-/m0/s1

InChIKey=HJEVREWNQJSEAV-BRKZGERCSA-N


Disulfide bonds: C2-C30; C4-C19; C9-C29 according to the DBAASP database; the EROP-Moscow database; the PeptideDB database

Antiviral peptide according to the APD database; the DBAASP database
Antifungal peptide according to the APD database; the CAMP database
Anticancer peptide according to the CancerPPD database


Database reference:
APD: ID AP00178

CAMP: ID CAMPSQ345

CancerPPD: ID cancerppd_4432

ChemSpider: ID 17292607

DBAASP: ID 6785

EROP-Moscow: ID E00585

PeptideDB: ID PEP06650

PubChem: CID 16136096

RSCB PDB: 1DFN

SATPdb: ID satpdb21751; satpdb25293