BIOPEP-UWM: Report

ID 3072
Name human defensin HNP-2
sequence
CYCRIPACIAGERRYGTCIYQGRLWAFCC
Function:
antibacterial
 
Number of residues
29
Activity code
ab
Activity :
antibacterial
Chemical mass 3376.9971 Monoisotopic mass 3374.5166
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Harwig S. S., Ganz T., Schilling J. W., Lehrer R. I.
Title
Primary structures of three human neutrophil defensins. J. Clin. Invest., 76, 1436-1439, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [C@H](N)(CS)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=C[N]C6=C5C=CC=C6)C(=O)N[C@@H](C)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(O)=O

InChI=1S/C147H223N43O37S6/c1-13-73(6)114(187-136(219)105(69-231)181-120(203)78(11)167-138(221)108-34-25-55-190(108)142(225)116(75(8)15-3)189-128(211)94(33-24-54-161-147(156)157)173-134(217)103(67-229)182-133(216)100(176-121(204)89(148)66-228)59-82-37-43-86(193)44-38-82)139(222)168-76(9)118(201)163-63-110(196)170-96(48-50-113(199)200)127(210)172-92(31-22-52-159-145(152)153)125(208)171-93(32-23-53-160-146(154)155)126(209)178-98(58-81-35-41-85(192)42-36-81)123(206)165-65-112(198)186-117(79(12)191)141(224)184-106(70-232)137(220)188-115(74(7)14-2)140(223)180-101(60-83-39-45-87(194)46-40-83)131(214)174-95(47-49-109(149)195)122(205)164-64-111(197)169-91(30-21-51-158-144(150)151)124(207)177-97(56-72(4)5)130(213)179-102(61-84-62-162-90-29-20-19-28-88(84)90)129(212)166-77(10)119(202)175-99(57-80-26-17-16-18-27-80)132(215)183-104(68-230)135(218)185-107(71-233)143(226)227/h16-20,26-29,35-46,62,72-79,89,91-108,114-117,162,191-194,228-233H,13-15,21-25,30-34,47-61,63-71,148H2,1-12H3,(H2,149,195)(H,163,201)(H,164,205)(H,165,206)(H,166,212)(H,167,221)(H,168,222)(H,169,197)(H,170,196)(H,171,208)(H,172,210)(H,173,217)(H,174,214)(H,175,202)(H,176,204)(H,177,207)(H,178,209)(H,179,213)(H,180,223)(H,181,203)(H,182,216)(H,183,215)(H,184,224)(H,185,218)(H,186,198)(H,187,219)(H,188,220)(H,189,211)(H,199,200)(H,226,227)(H4,150,151,158)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t73-,74-,75-,76-,77-,78-,79+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-/m0/s1

InChIKey=VSJBWFPEQNDVNW-HTLKCAKFSA-N


Disulfide bonds: C1-C29; C3-C18; C8-C28 according to the DBAASP database; the EROP-Moscow database; the PeptideDB database

Antiviral peptide according to the APD database; the DBAASP database
Hemolytic peptide according to the DBAASP database; the Hemolytik database
Antifungal peptide according to the APD database; the CAMP database
Anticancer peptide according to the CancerPPD database


Database reference:
APD: ID AP00177

CAMP: ID CAMPSQ2738

CancerPPD: ID cancerppd_4431

ChemSpider: ID 17292029

DBAASP: ID 5401

EROP-Moscow: ID E00584

Hemolytik: ID 2433

PeptideDB: ID PEP06647

PubChem: CID 16135512

RSCB PDB: 1ZMI

SATPdb: ID satpdb11499