BIOPEP-UWM: Report

ID 3073
Name human defensin HNP-1
sequence
ACYCRIPACIAGERRYGTCIYQGRLWAFCC
Function:
antibacterial
 
Number of residues
30
Activity code
ab
Activity :
antibacterial
Chemical mass 3448.0748 Monoisotopic mass 3445.5536
EC50 :
0.00 µM


Bibliographic data:
Authors
Selsted M. E., Harwig S. S., Ganz T., Schilling J. W., Lehrer R. I.
Title
Primary structures of three human neutrophil defensins. J. Clin. Invest., 76, 1436-1439, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [C@@H](C)(N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=C[N]C6=C5C=CC=C6)C(=O)N[C@@H](C)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(O)=O

InChI=1S/C150H228N44O38S6/c1-14-74(6)116(191-139(224)107(70-236)185-123(208)80(12)170-141(226)110-35-26-56-194(110)145(230)118(76(8)16-3)193-130(215)95(34-25-55-164-150(159)160)176-136(221)105(68-234)186-135(220)101(60-84-38-44-88(197)45-39-84)181-137(222)104(67-233)184-120(205)77(9)151)142(227)171-78(10)121(206)166-64-112(200)173-97(49-51-115(203)204)129(214)175-93(32-23-53-162-148(155)156)127(212)174-94(33-24-54-163-149(157)158)128(213)180-99(59-83-36-42-87(196)43-37-83)125(210)168-66-114(202)190-119(81(13)195)144(229)188-108(71-237)140(225)192-117(75(7)15-2)143(228)183-102(61-85-40-46-89(198)47-41-85)133(218)177-96(48-50-111(152)199)124(209)167-65-113(201)172-92(31-22-52-161-147(153)154)126(211)179-98(57-73(4)5)132(217)182-103(62-86-63-165-91-30-21-20-29-90(86)91)131(216)169-79(11)122(207)178-100(58-82-27-18-17-19-28-82)134(219)187-106(69-235)138(223)189-109(72-238)146(231)232/h17-21,27-30,36-47,63,73-81,92-110,116-119,165,195-198,233-238H,14-16,22-26,31-35,48-62,64-72,151H2,1-13H3,(H2,152,199)(H,166,206)(H,167,209)(H,168,210)(H,169,216)(H,170,226)(H,171,227)(H,172,201)(H,173,200)(H,174,212)(H,175,214)(H,176,221)(H,177,218)(H,178,207)(H,179,211)(H,180,213)(H,181,222)(H,182,217)(H,183,228)(H,184,205)(H,185,208)(H,186,220)(H,187,219)(H,188,229)(H,189,223)(H,190,202)(H,191,224)(H,192,225)(H,193,215)(H,203,204)(H,231,232)(H4,153,154,161)(H4,155,156,162)(H4,157,158,163)(H4,159,160,164)/t74-,75-,76-,77-,78-,79-,80-,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,116-,117-,118-,119-/m0/s1

InChIKey=BSPSKGRQDAMHAT-KSWODRSDSA-N


Disulfide bonds: C2-C30; C4-C19; C9-C29 according to the APD database; the EROP-Moscow database; the PeptideDB database


Anticancer peptide according to the CancerPPD database


Database reference:
APD: ID AP00176

AVPdb: ID avpdb_AVP1553, avpdb_AVP2029

CAMP: ID CAMPSQ692

CancerPPD: ID cancerppd_4430

ChemSpider: ID 17326738

EROP-Moscow: ID E00583

ParaPep: ID parapep_1144; parapep_1707

PeptideDB: ID PEP06646

PubChem: CID 16198328

RSCB PDB: 1ZMI

SATPdb: ID satpdb25628; satpdb27556