BIOPEP-UWM: Report
| ID | 3077 |
| Name | hirudin (54-65) |
| sequence |
| Function: | |||
| Inhibitor of fibrin clotting | |||
| Number of residues | 12 |
Activity code | at |
| Activity : | antithrombotic |
|||
| Chemical mass | 1468.5130 | Monoisotopic mass | 1467.6382 | |
| IC50 : | 3.70 µM |
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| Bibliographic data: | |
| Authors | |
| Payne M. H., Krstenansky J. L., Yates M. T., Mao S. J. | |
| Title | |
| Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J. Med. Chem., 34, 1184-1187, 1991 | |
| Year | Source |
| 1991 | Journal |
| Additional information: |
| BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(Cc1ccccc1)NC(=O)[C@]([H])(CC(O)=O)NC(=O)CN)[C@@H](C)CC)C(O)=O InChI=1S/C66H93N13O25/c1-5-34(4)55(78-59(96)41(21-26-53(89)90)71-56(93)38(18-23-50(83)84)72-61(98)44(29-35-10-7-6-8-11-35)77-63(100)46(31-54(91)92)69-49(82)32-67)65(102)79-27-9-12-47(79)64(101)73-40(20-25-52(87)88)57(94)70-39(19-24-51(85)86)58(95)76-45(30-36-13-15-37(80)16-14-36)62(99)75-43(28-33(2)3)60(97)74-42(66(103)104)17-22-48(68)81/h6-8,10-11,13-16,33-34,38-47,55,80H,5,9,12,17-32,67H2,1-4H3,(H2,68,81)(H,69,82)(H,70,94)(H,71,93)(H,72,98)(H,73,101)(H,74,97)(H,75,99)(H,76,95)(H,77,100)(H,78,96)(H,83,84)(H,85,86)(H,87,88)(H,89,90)(H,91,92)(H,103,104)/t34-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,55-/m0/s1 InChIKey=ZNEKMMIWGPUTGR-SQJOKQRMSA-N Another reference concerning peptide bioactivity: Kikuchi T., 1996, Prediction of location of active sites in biologically active peptides. J. Protein Chem.,15, 539-545 Inhibitor of hirudin-induced neutrophil chemotaxis according to the PepBank database |
| Database reference: |
| ChEMBL: ID CHEMBL411059 ChemSpider: ID 17295344 J-GLOBAL: ID 200907020416760498 Nikkaji: ID J378.864D PepBank: peptide GDFEEIPEEYLQ PubChem: CID 16138839 |