BIOPEP-UWM: Report

ID 3086
Name guinea pig defensin GPNP
sequence
RRCICTTRTCRFPYRRLGTCIFQNRVYTFCC
Function:
Antibacterial
 
Number of residues
31
Activity code
ab
Activity :
antibacterial
Chemical mass 3838.5584 Monoisotopic mass 3835.8345
EC50 :
0.00 µM


Bibliographic data:
Authors
Yamashita T., Saito K.
Title
Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides. Infect Immun., 57, 2405-2409, 1989
Year Source
1989 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(O)=O

InChI=1S/C164H262N54O41S6/c1-14-81(7)121(149(250)201-105(66-88-33-19-16-20-34-88)138(239)195-102(55-56-117(166)226)134(235)198-108(71-118(167)227)140(241)193-100(44-30-62-187-163(178)179)135(236)211-120(80(5)6)148(249)200-107(69-92-49-53-94(225)54-50-92)141(242)215-124(84(10)220)153(254)202-106(67-89-35-21-17-22-36-89)139(240)205-110(73-260)143(244)209-115(78-265)157(258)259)212-145(246)113(76-263)208-151(252)123(83(9)219)210-119(228)72-189-129(230)103(65-79(3)4)197-131(232)98(42-28-60-185-161(174)175)191-130(231)97(41-27-59-184-160(172)173)192-137(238)104(68-91-47-51-93(224)52-48-91)199-147(248)116-46-32-64-218(116)156(257)109(70-90-37-23-18-24-38-90)203-132(233)99(43-29-61-186-162(176)177)194-142(243)111(74-261)207-154(255)125(85(11)221)214-136(237)101(45-31-63-188-164(180)181)196-152(253)126(86(12)222)217-155(256)127(87(13)223)216-146(247)114(77-264)206-150(251)122(82(8)15-2)213-144(245)112(75-262)204-133(234)96(40-26-58-183-159(170)171)190-128(229)95(165)39-25-57-182-158(168)169/h16-24,33-38,47-54,79-87,95-116,120-127,219-225,260-265H,14-15,25-32,39-46,55-78,165H2,1-13H3,(H2,166,226)(H2,167,227)(H,189,230)(H,190,229)(H,191,231)(H,192,238)(H,193,241)(H,194,243)(H,195,239)(H,196,253)(H,197,232)(H,198,235)(H,199,248)(H,200,249)(H,201,250)(H,202,254)(H,203,233)(H,204,234)(H,205,240)(H,206,251)(H,207,255)(H,208,252)(H,209,244)(H,210,228)(H,211,236)(H,212,246)(H,213,245)(H,214,237)(H,215,242)(H,216,247)(H,217,256)(H,258,259)(H4,168,169,182)(H4,170,171,183)(H4,172,173,184)(H4,174,175,185)(H4,176,177,186)(H4,178,179,187)(H4,180,181,188)/t81-,82-,83+,84+,85+,86+,87+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,120-,121-,122-,123-,124-,125-,126-,127-/m0/s1

InChIKey=DBLYKWJHCMXYSZ-GCQOHTJFSA-N


Active agaist bacteria G(+), G(-) and fungi.
Disulfide bonds 3-31; 5-20; 10-30 according to the DBAASP database; the PeptideDB database


Antifungal peptide according to the CAMP database; the EROP-Moscow database
Antiviral peptide according to the CAMP database; the EROP-Moscow database


Database reference:
APD: ID AP00174

CAMP: ID CAMPSQ1053

DBAASP: ID 11357

EROP-Moscow: ID E00160

PeptideDB: ID PEP04326; PEP13562

SATPdb: ID satpdb12581