BIOPEP-UWM: Report

ID 3102
Name fragment of beta-amyloid protein:12-28
sequence
VHHQKLVFFAEDVGSNK
Function:
Beta-amyloid is a fragment of a protein that is snipped from another protein called amyloid precursor protein (APP). In a healthy brain, these protein fragments would be broken down and eliminated. In Alzheimer’s disease, the fragments accumulate to form hard, insoluble plaques.
 
Number of residues
17
Activity code
ne
Activity :
neuropeptide
Chemical mass 1955.1713 Monoisotopic mass 1954.0030
EC50 :
0.00 µM


Bibliographic data:
Authors
Castaño J. M., Ghiso J., Prelli F., Gorevic P. D., Migheli A., Frangione B.
Title
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochem. Biophys. Res. Commun., 141, 782-789, 1986
Year Source
1986 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [C@@H](C)(NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CN=C[N]3)NC(=O)[C@H](CC4=CN=C[N]4)NC(=O)[C@@H](N)C(C)C)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI=1S/C89H135N25O25/c1-45(2)32-58(106-75(124)54(24-16-18-30-90)103-76(125)55(26-28-66(92)116)104-80(129)61(35-52-39-95-43-98-52)108-81(130)62(36-53-40-96-44-99-53)111-86(135)71(94)46(3)4)83(132)114-73(48(7)8)88(137)112-60(34-51-22-14-11-15-23-51)79(128)107-59(33-50-20-12-10-13-21-50)78(127)100-49(9)74(123)102-56(27-29-69(119)120)77(126)110-64(38-70(121)122)84(133)113-72(47(5)6)87(136)97-41-68(118)101-65(42-115)85(134)109-63(37-67(93)117)82(131)105-57(89(138)139)25-17-19-31-91/h10-15,20-23,39-40,43-49,54-65,71-73,115H,16-19,24-38,41-42,90-91,94H2,1-9H3,(H2,92,116)(H2,93,117)(H,95,98)(H,96,99)(H,97,136)(H,100,127)(H,101,118)(H,102,123)(H,103,125)(H,104,129)(H,105,131)(H,106,124)(H,107,128)(H,108,130)(H,109,134)(H,110,126)(H,111,135)(H,112,137)(H,113,133)(H,114,132)(H,119,120)(H,121,122)(H,138,139)/t49-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,71-,72-,73-/m0/s1

InChIKey=WOMPQPMHRDDZMP-IJBWYZRXSA-N


Database reference:

ChEMBL: ID CHEMBL4074607

ChemSpider: ID 25069818

PubChem: CID 24868224