BIOPEP-UWM: Report

ID 3104
Name fragment of beta-amyloid protein: 1-16
sequence
DAEFRHDSGYQVHHQK
Function:
Beta-amyloid is a fragment of a protein that is snipped from another protein called amyloid precursor protein (APP). In a healthy brain, these protein fragments would be broken down and eliminated. In Alzheimer’s disease, the fragments accumulate to form hard, insoluble plaques.
 
Number of residues
16
Activity code
ne
Activity :
neuropeptide
Chemical mass 1954.0182 Monoisotopic mass 1952.8851
EC50 :
0.00 µM


Bibliographic data:
Authors
Castaño J. M., Ghiso J., Prelli F., Gorevic P. D., Migheli A., Frangione B.
Title
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease b-protein. Biochem. Biophys. Res. Commun., 141, 782-789, 1986
Year Source
1986 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [C@H](N)(CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CN=C[N]2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC4=CN=C[N]4)C(=O)N[C@@H](CC5=CN=C[N]5)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI=1S/C84H120N28O27/c1-41(2)68(82(137)110-59(30-47-35-93-40-98-47)80(135)108-57(28-45-33-91-38-96-45)78(133)103-51(18-21-62(87)115)73(128)105-54(83(138)139)12-7-8-24-85)112-75(130)52(19-22-63(88)116)104-76(131)55(27-44-14-16-48(114)17-15-44)100-64(117)36-95-71(126)61(37-113)111-81(136)60(32-67(122)123)109-79(134)58(29-46-34-92-39-97-46)107-72(127)50(13-9-25-94-84(89)90)102-77(132)56(26-43-10-5-4-6-11-43)106-74(129)53(20-23-65(118)119)101-69(124)42(3)99-70(125)49(86)31-66(120)121/h4-6,10-11,14-17,33-35,38-42,49-61,68,113-114H,7-9,12-13,18-32,36-37,85-86H2,1-3H3,(H2,87,115)(H2,88,116)(H,91,96)(H,92,97)(H,93,98)(H,95,126)(H,99,125)(H,100,117)(H,101,124)(H,102,132)(H,103,133)(H,104,131)(H,105,128)(H,106,129)(H,107,127)(H,108,135)(H,109,134)(H,110,137)(H,111,136)(H,112,130)(H,118,119)(H,120,121)(H,122,123)(H,138,139)(H4,89,90,94)/t42-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,68-/m0/s1

InChIKey=BAJSMSBUNHRDLE-GXMMQULOSA-N


Database reference: