BIOPEP-UWM: Report

ID 3172
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
VA
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 188.2236 Monoisotopic mass 188.1157
IC50 :
168.24 µM


Bibliographic data:
Authors
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
Title
Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644–653
Year Source
2013 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O

InChI=1S/C8H16N2O3/c1-4(2)6(9)7(11)10-5(3)8(12)13/h4-6H,9H2,1-3H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1

InChIKey: HSRXSKHRSXRCFC-WDSKDSINSA-N


The first reference concerning peptide:
Bella A. M., Erickson R. H. Jr., Kim Y. S. Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specifcities of the purified enzyme. Arch. Biochem. Biophys. 218 (1), 156-162 (1982)


Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the ChEMBL database
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database


Database reference:
AHTPDB: ID 3848

BIOPEP-UWM database of sensory peptides and amino acids: ID 462

BRENDA: Ligand Val-Ala

ChEBI: ID 75008

ChEMBL: ID CHEMBL55523

ChemSpider: ID 5360762

CompTox: ID DTXSID60426328

EPA DSSTox: ID DTXCID40377162

EROP-Moscow: ID E09235

J-GLOBAL: ID 200907035026970731

Nikkaji: ID J149.658A

PubChem: CID 6992637

SATPdb: ID satpdb14267

ZINC: ID ZINC01578617