BIOPEP-UWM: Report

ID 3178
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
GPPPPGPPPI
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
10
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 925.0791 Monoisotopic mass 924.5053
EC50 :
500.00 µM


Bibliographic data:
Authors
Lacroix I. M. E., Li-Chan E. C. Y.
Title
Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)CN)C(O)=O

InChI=1S/C45H68N10O11/c1-3-27(2)37(45(65)66)48-39(59)29-12-5-21-52(29)43(63)33-16-8-22-53(33)41(61)31-14-7-19-50(31)36(57)26-47-38(58)28-11-4-20-51(28)42(62)32-15-9-24-55(32)44(64)34-17-10-23-54(34)40(60)30-13-6-18-49(30)35(56)25-46/h27-34,37H,3-26,46H2,1-2H3,(H,47,58)(H,48,59)(H,65,66)/t27-,28-,29-,30-,31-,32-,33-,34-,37-/m0/s1

InChIKey=WTMGGHFYHAKEIM-UBZVIJGOSA-N

Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: S09.003


Peptide found in amaranth (Amarantus hypochondriacus) proteins:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) according to AHTPDB database; BIOPEP database of bioactive peptides (ID 3502); EROP-Moscow database
Antifungal peptide according to EROP-Moscow database

Bitter peptide according to BIOPEP database of sensory peptides and amino acids; EROP-Moscow database


Database reference:
AHTPDB: ID 1135; 1334; 1366; 1664; 1743; 2580; 3181; 3204; 3396; 3556; 3596; 3878; 3909; 4071; 4161; 4728; 4949; 5147; 5417; 5565; 5585; 5702; 5948; 6421; 6865
BIOPEP database of bioactive peptides: ID 3502
BIOPEP database of sensory peptides and amino acids: ID 45
BRENDA: Ligand Phe-Pro
ChEBI: ID 74750
ChEMBL: ID CHEMBL1807686
ChemSpider ID: 5383590
EROP-Moscow: ID E04808; E01602; E03693; E09206
PubChem: ID 7020641
ZINC: ID ZINC02392313