BIOPEP-UWM: Report

ID 3180
Name dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
sequence
LP
Function:
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
 
Number of residues
2
Activity code
dpp
Activity :
dipeptidyl peptidase IV inhibitor
Chemical mass 228.2873 Monoisotopic mass 228.1469
IC50 :
2370.00 µM


Bibliographic data:
Authors
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Title
Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chem., 134, 797-802, 2012
Year Source
2012 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)O

InChI=1S/C11H20N2O3/c1-7(2)6-8(12)10(14)13-5-3-4-9(13)11(15)16/h7-9H,3-6,12H2,1-2H3,(H,15,16)/t8-,9-/m0/s1

InChIKey: VTJUNIYRYIAIHF-IUCAKERBSA-N



First reference concerning peptide:
Bella A. M., Erickson R. H. Jr., Kim Y. S., Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme.Arch.Biochem.Biophys. 218 (1), 156-162(1982)

Alternative IC50 value: 712.5 micromoles according to:
Nongonierma A. B., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 10092)
Inhibitor of Xaa-Pro dipeptidase (EC 3.4.13.9) (MEROPS ID: M24.003) according to the BRENDA database
Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to the BRENDA database
Peptide inducing the secretion of interferon-gamma by human CD+,4 T-lymphocytes according to the EROP-Moscow database

Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 528)


Database reference:
AHTPDB: ID 4061

BindingDB: ID 50169151

BioPepDB: ID biopep00845

BIOPEP-UWM database of bioactive peptides: ID 10092

BIOPEP-UWM database of sensory peptides and amino acids: ID 528

BRENDA: Ligand Leu-Pro

ChEBI: ID 73580

ChEMBL: ID CHEMBL189210

ChemIDplus: ID 006403356

ChemSpider: ID 72971

EPA CompTox: ID DTXSID30214012

EPA DSSTox: ID DTXCID30136503

EROP-Moscow: ID E02539

FeptideDB: ID 3180

J-GLOBAL: ID 200907029039792069

Nikkaji: ID J151.043F

PubChem: ID 11893568

SATPdb: ID satpdb26580

SureChEMBL: ID SCHEMBL3052903

ZINC: ID ZINC04556774