BIOPEP-UWM: Report

ID 3185
Name Dermaseptin S1
sequence
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Function:
Antibacterial
 
Number of residues
34
Activity code
ab
Activity :
antibacterial
Chemical mass 3455.0506 Monoisotopic mass 3452.8577
EC50 :
0.00 µM


Bibliographic data:
Authors
Mor A., Nguyen V. H., Delfour A., Migliore-Samour D., Nicolas P.
Title
Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry., 30, 8824-8830, 1991
Year Source
1991 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O

InChI=1S/C152H257N43O44S2/c1-27-77(12)118(147(233)190-110(70-196)146(232)178-98(44-46-111(158)201)131(217)163-68-115(205)192-120(87(22)198)149(235)181-101(152(238)239)45-47-112(159)202)193-151(237)122(89(24)200)195-145(231)109(63-117(207)208)185-129(215)84(19)169-126(212)81(16)168-125(211)80(15)167-113(203)66-164-132(218)102(56-72(2)3)183-128(214)83(18)170-127(213)82(17)172-134(220)94(40-30-34-50-153)174-114(204)67-162-124(210)79(14)171-140(226)108(62-91-65-160-71-166-91)189-143(229)105(59-75(8)9)184-130(216)85(20)173-135(221)99(48-54-240-25)179-148(234)119(86(21)197)191-116(206)69-165-133(219)103(57-73(4)5)186-137(223)96(42-32-36-52-155)175-136(222)95(41-31-35-51-154)176-141(227)106(60-76(10)11)187-138(224)100(49-55-241-26)180-150(236)121(88(23)199)194-139(225)97(43-33-37-53-156)177-144(230)107(61-90-64-161-93-39-29-28-38-92(90)93)188-142(228)104(58-74(6)7)182-123(209)78(13)157/h28-29,38-39,64-65,71-89,94-110,118-122,161,196-200H,27,30-37,40-63,66-70,153-157H2,1-26H3,(H2,158,201)(H2,159,202)(H,160,166)(H,162,210)(H,163,217)(H,164,218)(H,165,219)(H,167,203)(H,168,211)(H,169,212)(H,170,213)(H,171,226)(H,172,220)(H,173,221)(H,174,204)(H,175,222)(H,176,227)(H,177,230)(H,178,232)(H,179,234)(H,180,236)(H,181,235)(H,182,209)(H,183,214)(H,184,216)(H,185,215)(H,186,223)(H,187,224)(H,188,228)(H,189,229)(H,190,233)(H,191,206)(H,192,205)(H,193,237)(H,194,225)(H,195,231)(H,207,208)(H,238,239)/t77-,78-,79-,80-,81-,82-,83-,84-,85-,86+,87+,88+,89+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,118-,119-,120-,121-,122-/m0/s1

InChIKey=YFHLIDBAPTWLGU-CTKMSOPVSA-N


Hemolytic peptide according to the ChEMBL database; the DBAASP database; the Hemolytik database
Cytotoxic peptide according to the DBAASP database
Antiviral peptide according to the EROP-Moscow database
Anticancer peptide according to the CancerPPD database


Database reference:
ACToR: ID 136212-91-4

APD: ID AP00157

CancerPPD: ID 1708

ChEMBL: ID CHEMBL52520

ChemIDplus: ID 136212-91-4

ChemSpider: ID 17287210

ClinicalTrials: Compound Dermaseptin S1

CTD: ID 136212-91-4

DADP: ID SP_P24302

DBAASP: ID 991

EROP-Moscow database: ID E01254

Hemolytik: ID 3690; 3986

ParaPep: ID 1345; 1442; 1443; 1444; 1445

PeptideDB: ID PEP05171; PEP15516
PubChem CID: 16130489

SATPdb: ID satpdb28956