BIOPEP-UWM: Report

ID 3195
Name Precursor of hemolytic peptide
sequence
FLPLAIGLLGKLFG
Function:
Precursor of hemolytic peptide
 
Number of residues
14
Activity code
he
Activity :
haemolytic
Chemical mass 1458.8234 Monoisotopic mass 1457.8982
EC50 :
0.00 µM


Bibliographic data:
Authors
Simmaco M., Mignogna G., Barra D., Bossa F.
Title
Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. FEBS Lett., 324, 159-161, 1993
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)NCC(O)=O

InChI=1S/C74H119N15O15/c1-14-47(12)63(88-64(94)48(13)80-69(99)55(34-44(6)7)86-72(102)59-29-23-31-89(59)74(104)58(36-46(10)11)87-65(95)51(76)37-49-24-17-15-18-25-49)73(103)78-40-61(91)82-54(33-43(4)5)70(100)83-53(32-42(2)3)66(96)77-39-60(90)81-52(28-21-22-30-75)68(98)84-56(35-45(8)9)71(101)85-57(67(97)79-41-62(92)93)38-50-26-19-16-20-27-50/h15-20,24-27,42-48,51-59,63H,14,21-23,28-41,75-76H2,1-13H3,(H,77,96)(H,78,103)(H,79,97)(H,80,99)(H,81,90)(H,82,91)(H,83,100)(H,84,98)(H,85,101)(H,86,102)(H,87,95)(H,88,94)(H,92,93)/t47-,48-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1

InChIKey=IDTCJNBLZPUTCJ-NGVBFQBYSA-N


The active form is C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of hemolytic peptide (ID 3194 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: