BIOPEP-UWM: Report

ID 3221
Name Precursor of antibacterial peptide
sequence
GLLSVLGSVAKHVLPHVVPVIAEHLG
Function:
Precursor of antibacterial peptide
 
Number of residues
26
Activity code
ab
Activity :
antibacterial
Chemical mass 2642.1381 Monoisotopic mass 2640.5432
EC50 :
0.00 µM


Bibliographic data:
Authors
Wong H., Bowie J. H., Carver J. A.
Title
The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida. Eur. J. Biochem., 247, 545-557, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: [H][C@@](C)(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CO)NC(=O)CNC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CO)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)CN)C(C)C)C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(O)=O

InChI=1S/C123H205N33O31/c1-27-70(24)100(121(185)135-72(26)102(166)139-77(35-36-92(161)162)106(170)142-82(45-73-49-126-56-131-73)109(173)140-78(40-59(2)3)104(168)130-53-93(163)164)154-120(184)98(68(20)21)152-115(179)89-34-31-39-156(89)123(187)99(69(22)23)153-119(183)97(67(18)19)149-111(175)84(47-75-51-128-58-133-75)144-114(178)88-33-30-38-155(88)122(186)85(44-63(10)11)146-118(182)96(66(16)17)148-110(174)83(46-74-50-127-57-132-74)143-105(169)76(32-28-29-37-124)138-101(165)71(25)134-116(180)94(64(12)13)150-112(176)86(54-157)137-91(160)52-129-103(167)79(41-60(4)5)145-117(181)95(65(14)15)151-113(177)87(55-158)147-108(172)81(43-62(8)9)141-107(171)80(42-61(6)7)136-90(159)48-125/h49-51,56-72,76-89,94-100,157-158H,27-48,52-55,124-125H2,1-26H3,(H,126,131)(H,127,132)(H,128,133)(H,129,167)(H,130,168)(H,134,180)(H,135,185)(H,136,159)(H,137,160)(H,138,165)(H,139,166)(H,140,173)(H,141,171)(H,142,170)(H,143,169)(H,144,178)(H,145,181)(H,146,182)(H,147,172)(H,148,174)(H,149,175)(H,150,176)(H,151,177)(H,152,179)(H,153,183)(H,154,184)(H,161,162)(H,163,164)/t70-,71-,72-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,94-,95-,96-,97-,98-,99-,100-/m0/s1

InChIKey=ZEBMYLOTXINJEN-ZAOQFSNRSA-N


The active form of this peptide contains C-terminal amide group instead of C-terminal glycine residue.

Peptide is the precursor of antibacterial peptide (ID 3222 in BIOPEP-UWM database of bioactive peptides).

Reviews concerning C-terminal amidation of peptides:

Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115

Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456


Database reference: