BIOPEP-UWM: Report

ID 3225
Name Brevinin-1E
sequence
FLPLLAGLAANFLPKIFCKITRKC
Function:
antibacterial
 
Number of residues
24
Activity code
ab
Activity :
antibacterial
Chemical mass 2678.3444 Monoisotopic mass 2676.5328
EC50 :
0.00 µM


Bibliographic data:
Authors
Simmaco M., Mignogna G., Barra D., Bossa F.
Title
Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. FEBS Lett., 324, 159-161, 1993
Year Source
1993 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(O)=O

InChI=1S/C128H209N31O27S2/c1-19-74(13)102(122(180)150-92(64-82-43-28-23-29-44-82)117(175)153-96(67-187)119(177)143-85(46-31-34-52-130)111(169)156-103(75(14)20-2)123(181)157-104(79(18)160)124(182)145-87(48-36-54-136-128(134)135)109(167)142-84(45-30-33-51-129)110(168)154-97(68-188)127(185)186)155-112(170)86(47-32-35-53-131)144-120(178)98-49-37-55-158(98)126(184)95(61-73(11)12)152-116(174)91(63-81-41-26-22-27-42-81)148-118(176)93(65-100(133)161)146-107(165)78(17)138-106(164)77(16)140-113(171)88(57-69(3)4)141-101(162)66-137-105(163)76(15)139-114(172)89(58-70(5)6)147-115(173)90(59-71(7)8)149-121(179)99-50-38-56-159(99)125(183)94(60-72(9)10)151-108(166)83(132)62-80-39-24-21-25-40-80/h21-29,39-44,69-79,83-99,102-104,160,187-188H,19-20,30-38,45-68,129-132H2,1-18H3,(H2,133,161)(H,137,163)(H,138,164)(H,139,172)(H,140,171)(H,141,162)(H,142,167)(H,143,177)(H,144,178)(H,145,182)(H,146,165)(H,147,173)(H,148,176)(H,149,179)(H,150,180)(H,151,166)(H,152,174)(H,153,175)(H,154,168)(H,155,170)(H,156,169)(H,157,181)(H,185,186)(H4,134,135,136)/t74-,75-,76-,77-,78-,79+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,102-,103-,104-/m0/s1

InChIKey=MWNCCZICDUEXEK-SCGWVUOMSA-N


Disulfide bond between C18 and C24 according to the PeptideDB database


Hemolytic peptide according to the Hemolytik database


Database reference:
APD: ID AP00073

CAMP: ID CAMPSQ598; CAMPSQ1765; CAMPSQ4355

DADP: ID SP_P32412

EROP-Moscow: ID E01382

Hemolytik: ID 1602; 1606; 2147; 3285; 3286; 3302; 3683

PeptideDB: ID PEP05544; PEP08435

SATPdb: ID satpdb12342; satpdb15685