BIOPEP-UWM: Report

ID 3258
Name beta-lactokinin
sequence
IR
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 287.3576 Monoisotopic mass 287.1952
IC50 :
695.00 µM


Bibliographic data:
Authors
Mullally M. M., Meisel H., FitzGerald R. J.
Title
Synthetic peptides corresponding to -lactalbumin and -lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261
Year Source
1996 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C12H25N5O3/c1-3-7(2)9(13)10(18)17-8(11(19)20)5-4-6-16-12(14)15/h7-9H,3-6,13H2,1-2H3,(H,17,18)(H,19,20)(H4,14,15,16)/t7-,8-,9-/m0/s1

InChIKey=HYXQKVOADYPQEA-CIUDSAMLSA-N


Another value of peptide EC50 = 2.25 um

Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476

Isolated from pea protein hydrolysate.
Li H., Aluko R. E., 2010, Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate. J. Agric. Food Chem., 58, 11471-11476

Isolated from hen ovotransferrin hydrolysate
Huang W.-Y., Majumder K., Wu J., 2010, Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interactions with phytochemicals. Food Chem., 123, 635-641

Found in amaranth (Amarantus hypochondriacus) proteins:
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8215)
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 8246)
Inhibitor of calmodulin-dependent phosphodiesterase 1 (CaMPDE) (EC 3.1.4.17) according to the BIOPEP-UWM database of bioactive peptides (ID 8247)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8806)


Database reference:
AHTPDB: ID 1148, 1433, 1508, 3163, 3195, 3501, 3566, 3958, 4082, 5596, 5859

BioPepDB: ID biopep00580

BIOPEP-UWM database of bioactive peptides: ID 8215; 8246; 8247; 8806

BRENDA: Ligand Ile-Arg

ChEBI: ID 74061

ChemSpider: ID 5384711

EROP-Moscow: ID E09248

MBPDB: peptide IR

PubChem: CID 7021814

SATPdb: ID satpdb20125