BIOPEP-UWM: Report

ID 3261
Name beta-lactokinin (fr. of beta-lactoglobulin: 142-148)
sequence
ALPMHIR
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
7
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 837.0432 Monoisotopic mass 836.4677
IC50 :
43.00 µM


Bibliographic data:
Authors
Mullally M., Meisel H., FitzGerald R. J.
Title
Identification of a novel angiotensin I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine beta-Lg. FEBS Lett., 402, 99-102, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C37H64N12O8S/c1-7-21(4)29(34(54)45-25(36(56)57)10-8-13-42-37(39)40)48-32(52)26(17-23-18-41-19-43-23)46-31(51)24(12-15-58-6)44-33(53)28-11-9-14-49(28)35(55)27(16-20(2)3)47-30(50)22(5)38/h18-22,24-29H,7-17,38H2,1-6H3,(H,41,43)(H,44,53)(H,45,54)(H,46,51)(H,47,50)(H,48,52)(H,56,57)(H4,39,40,42)/t21-,22-,24-,25-,26-,27-,28-,29-/m0/s1

InChIKey=ZPQOMIXBBOSUPU-PNZHTLIDSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide stimulating proliferation of splenocytes according to the MBPDB database
Peptide reducing endothelin-1 release according to the MBPDB database

Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB: 6M03 and PDB: 6LU7) according to the BIOPEP-UWM Virtual database (ID 25)


Database reference:
AHTPDB: ID 1122, 1322, 2417, 3676, 3736, 3778, 4266, 4328, 5858

BioPepDB: ID biopep00053

BIOPEP-UWM Virtual: ID 25

EROP-Moscow: ID E02856

FeptideDB: ID 3261

J-GLOBAL: ID 200907074317118850

MBPDB: Peptide ALPMHIR

MeSH: terms lactokinin; ALPMHIR; ALPMHIR peptide

Nikkaji: ID J812.290C

PepBank: Peptide ALPMHIR

PubChem: CID 9988076

SATPdb: ID satpdb21866

UniChem: compound ZPQOMIXBBOSUPU-PNZHTLIDSA-N

ZINC: ID ZINC000195864225