BIOPEP-UWM: Report

ID 3262
Name beta-casomorphin-7 (60-66)
sequence
YPFPGPI

Function:
Opioid agonist
 
Number of residues
7
Activity code
op1
Activity :
opioid agonist
Chemical mass 789.9147 Monoisotopic mass 789.4048
EC50 :
14.00 µM



Bibliographic data:
Authors
Henschen A., Lottspeich F., Brantl V., Teschemacher H.
Title
Novel opioid peptides derivrd from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone. Hoppe-Seyler's Z. Physiol. Chem., 360, 1217-1224, 1979
Year Source
1979 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O

InChI=1S/C41H55N7O9/c1-3-25(2)35(41(56)57)45-38(53)32-13-7-19-46(32)34(50)24-43-36(51)31-12-8-21-48(31)40(55)30(23-26-10-5-4-6-11-26)44-37(52)33-14-9-20-47(33)39(54)29(42)22-27-15-17-28(49)18-16-27/h4-6,10-11,15-18,25,29-33,35,49H,3,7-9,12-14,19-24,42H2,1-2H3,(H,43,51)(H,44,52)(H,45,53)(H,56,57)/t25-,29-,30-,31-,32-,33-,35-/m0/s1

INChiKey: RKYJTDSQXOMDAD-JKXTZXEVSA-N


Another reference concerning opioid activity:

Meisel H., 1998, Overview on milk protein-derived peptides. Int. Dairy J., 8, 363-373


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to AHTPDB database; BIOPEP-UWM database of bioactive peptides (ID 7665)
Inhibitor of Cathepsin B (EC 3.4.22.1) (MEROPS ID: C01.060) according to PepBank database
Immunomodulatory peptide according to the BIOPEP-UWM database of bioactivew peptides (ID 9281); the MBPDB database
Anticancer peptide according to the BIOPEP-UWM database of bioactivew peptides (ID 9176), the MBPDB database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10050), the MBPDB database
Inhibitor of Acetylcholinesterase (EC 3.1.1.7) according to the BIOPEP-UWM database of bioactive peptides (ID 10240)
Inhibitor of Butyrylcholinesterase (EC 3.1.1.8) according to the BIOPEP-UWM database of bioactive peptides (ID 10241)


Potentially antithrombotic peptide according to the BIOPEP-UWM Virtual database; the DFPB database (ID 187)


Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids (ID 136)



Database reference:
ACToR: ID 72122-62-4

AHTPDB: ID 2476; 3430; 3461; 4268; 6651

BindingDB: ID 50089072

BioPepDB: ID biopep01594

BIOPEP-UWM database of bioactive peptides: ID 7665; 9176; 9281; 10050; 10 240; 10241

BIOPEP-UWM database of sensory peptides and amino acids: ID 136

BIOPEP-UWM Virtual database: ID 187

BRENDA: Ligand Tyr-Pro-Phe-Pro-Gly-Pro-Ile

CAS: Registry No 72122-62-4

ChEMBL: ID CHEMBL2370605

ChemIDplus: ID 072122624

ChemSpider: ID ID108788

DFBP: ID DFBPACEI0345; DFBPANTH0169; DFBPOPIO0011; DFBPMUFU0103

EROP-Moscow: ID E00233

FeptideDB: ID 3262; 7665

J-GLOBAL: ID 200907086748608208

MBPDB: Peptide YPFPGPI

Nikkaji: ID J39.399A

PepBank: Peptide YPFPGPI

PubChem: CID 121946

SatpDB; ID satpdb27350