BIOPEP-UWM: Report

ID 3373
Name ACE inhibitor from beta-CN
sequence
PQR

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 399.4442 Monoisotopic mass 399.2224
IC50 :
401.00 µM



Bibliographic data:
Authors
Meisel H.
Title
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality. ed. Schwenke K. D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75, 1993
Year Source
1993 book



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(O)=O

InChI=1S/C16H29N7O5/c17-12(24)6-5-10(22-13(25)9-3-1-7-20-9)14(26)23-11(15(27)28)4-2-8-21-16(18)19/h9-11,20H,1-8H2,(H2,17,24)(H,22,25)(H,23,26)(H,27,28)(H4,18,19,21)/t9-,10-,11-/m0/s1

InChIKey=LSIWVWRUTKPXDS-DCAQKATOSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference:
AHTPDB: ID 1178, 3386, 4010, 4103, 5617, 5856, 6358,

EROP-Moscow: ID E09261

FeptideDB: ID 3373

PubChem: CID 145457442

SATPdb: ID satpdb28276