BIOPEP-UWM: Report

ID 3380
Name ACE inhibitor
sequence
RY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 337.3733 Monoisotopic mass 337.1745
EC50 :
10.50 µM


Bibliographic data:
Authors
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Title
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O

InChI=1S/C15H23N5O4/c16-11(2-1-7-19-15(17)18)13(22)20-12(14(23)24)8-9-3-5-10(21)6-4-9/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1

InChIKey=XTWSWDJMIKUJDQ-RYUDHWBXSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10051)
Inhibitor of lysine/arginine leucyltransferase (EC 2.3.2.6) according to the BRENDA database


Database reference:
AHTPDB: ID 1094, 1186, 1356, 1375, 3196, 3536, 3597, 4024, _4112, ahtpdb_4706, 5171, 5622, 6172, 6364

BindingDB: ID 50049711

BioPepDB: ID biopep01231

BIOPEP-UWM database of bioactive peptides: ID 10051

BRENDA: Ligand Arg-Tyr

ChEBI: ID 73822

ChEMBL: ID CHEMBL3321986

ChemSpider: ID ID5384366

EPA CompTox: ID DTXSID90427363

EPA DSSTox: ID DTXSID90427363

EROP-Moscow: ID E01334

FeptideDB: ID 3380

HMDB: ID HMDB0028721

J-GLOBAL: ID 200907049958236513

MBPDB: Peptide RY

Metabolights: ID MTBLC73822

Nikkaji: ID J36.198D

PantPepDB: ID PPepDB_184

PubChem: CID 7021456

SATPdb: ID satpdb16420

SureChEMBL: ID SCHEMBL3303678

ZINC: ID ZINC000002572104