BIOPEP-UWM: Report

ID 3383
Name ACE inhibitor
sequence
IY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 294.3453 Monoisotopic mass 294.1574
IC50 :
2.10 µM


Bibliographic data:
Authors
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Title
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)[C@H](CC)C

InChI=1S/C15H22N2O4/c1-3-9(2)13(16)14(19)17-12(15(20)21)8-10-4-6-11(18)7-5-10/h4-7,9,12-13,18H,3,8,16H2,1-2H3,(H,17,19)(H,20,21)/t9-,12-,13-/m0/s1

InChIKey: MUFXDFWAJSPHIQ-XDTLVQLUSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

IC50(EC50) of peptide ranges from 2,1 to 3,7 uM.

Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45

Peptide obtained from the following resources:

soybean protein hydrolysate
Beermann C., Euler M., Herzberg J., Stahl B., 2009, Anti-oxidative capacity of enzymatically released peptides from soybean protein isolate. Eur. Food Res. Technol., 229, 637–644

amaranth proteins:
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

bovine collagen hydrolysate:

Herregods G., Van Camp J., Morel N., Ghesquière B., Gevaert K., Vercruysse L., Dierckx S., Quanten E., Smagghe G., 2011, Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides. J. Agric. Food Chem., 59, 552-558


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7873); the PlantPepDB database


Database reference:
AHTPDB: ID 1070; 1098; 1150, 1287, 1348, 1353, 1373, 1377, 1411, 1440, 1495, 1510, 1818, 1855, 1903, 1934, 1948, 2583, 2734, 2778, 2956, 2988, 2992, 3064, 3166, 3171, 3197, 3504, 3781, 3962, 4083, 4226, 4248, 4253, 4259, 4450, 4487, 4652, 4947, 4955, 4956, 4957, 5156, 5598, 5661, 6140, 6143, 6176, 6263, 6268, 6282, 6367, 6879

Binding DB: ID 50038069

BioPepDB: ID biopep00619

BIOPEP-UWM database of bioactive peptides: ID 7873

BRENDA: Ligand Ile-Tyr

ChEBI: ID 74326

ChEMBL: ID CHEMBL91090

ChemSpider: ID 5730945

EROP-Moscow: ID E01439

FeptideDB: ID 3383; 7873

J-GLOBAL: ID 200907037450857360

Metabolights: ID MTBLC74326

Metabolomics Workbench: ID 71683

Nikkaji: ID J535.351C

PlantPepDB: ID PPepDB_3792

PubChem: CID 7408194

SATPdb: ID satpdb18728

SureChEMBL: ID SCHEMBL4261778

ZINC: ID ZINC000004899517