BIOPEP-UWM: Report

ID 3388
Name ACE inhibitor
sequence
MY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 312.3849 Monoisotopic mass 312.1139
IC50 :
193.00 µM


Bibliographic data:
Authors
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Title
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245, 1994
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCSC)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C14H20N2O4S/c1-21-7-6-11(15)13(18)16-12(14(19)20)8-9-2-4-10(17)5-3-9/h2-5,11-12,17H,6-8,15H2,1H3,(H,16,18)(H,19,20)/t11-,12-/m0/s1

InChIKey=PESQCPHRXOFIPX-RYUDHWBXSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8838)
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8090)
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BIOPEP-UWM database of bioactive peptides; the BRENDA database


Database reference:
AHTPDB: ID 1095, 1357, 2792, 3997, 4726, 5166, 5615, 6173, 6372

BIOPEP-UWM database of bioactive peptides: ID 8090; 8838

BRENDA: Ligand Met-Tyr-OH

CAS: Registry No 13589-04-3

ChEBI: ID 73615

ChemSpider: ID 5373137

EPA CompTox: ID DTXSID10874592

EROP-Moscow: ID E01332

J-GLOBAL: ID 200907099510465373

Metabolomics Workbench: ID 78914

Nikkaji: ID J81.650G

PubChem: CID 7009558

SATPdb: ID satpdb13539

SureChEMBL: ID SCHEMBL7609995

Wikidata: ID Q27141932