BIOPEP-UWM: Report

ID 3389
Name ACE inhibitor from alphas1-CN
sequence
LW
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 317.3819 Monoisotopic mass 317.1734
IC50 :
50.00 µM


Bibliographic data:
Authors
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Title
Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586, 1987
Year Source
1987 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)CC(C)C

InChI=1S/C17H23N3O3/c1-10(2)7-13(18)16(21)20-15(17(22)23)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1

InChIKey: BQVUABVGYYSDCJ-ZFWWWQNUSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Another value of peptide IC50(EC50)=17.40 uM

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci., 68, 1611-1614

Peptide found in chum salmon muscle protein hydrolysate.

Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci., 68, 1611-1614

Peptide found in amaranth protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides; the BRENDA database
Inhibitor of Dipeptidyl-peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8688)
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BIOPEP database of bioactive peptides (ID 2832); the BRENDA database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8462)


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids; the BitterDB database; the ChEMBL database; the PubChem database


Database reference:
AHTPDB: ID 1086; 1172; 1378; 1385; 1445; 1469; 1860; 2043; 2079; 2105; 2150; 2606; 2789; 3298; 3575; 3763; 3855; 3992; 4098; 4141; 4201; 4238; 4389; 4468; 4714; 4952; 5162; 5612; 6161; 6273; 6373

BindingDB: ID 50049754

BioPepDB: ID biopep00934

BIOPEP-UWM database of bioactive peptides: ID 2832; 8462; 8688; 9498

BIOPEP-UWM database of sensory peptides and amino acids: ID 337

BitterDB: ID 828

BRENDA: Ligand Leu-Trp

ChEBI: ID 73590

ChEMBL: ID CHEMBL56154

ChemSpider: ID 5360459

EROP-Moscow: ID E09194

J-GLOBAL: ID 200907041657441765

MBPDB: peptide LW

Metabolights: ID MTBLC73590

Nikkaji: ID J151.283H

PubChem: ID 6992319

SATPdb: ID satpdb27808

SureChEMBL: ID SCHEMBL5369872

ZINC: ID ZINC01570252