BIOPEP-UWM: Report

ID 3391
Name ACE inhibitor
sequence
LPP

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 325.4022 Monoisotopic mass 325.1995
EC50 :
9.60 µM



Bibliographic data:
Authors
Maruyama S., Miyoshi S., Kaneko T., Tanaka H.
Title
Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein. Agric. Biol. Chem., 53, 1077-1081, 1989
Year Source
1989 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C16H27N3O4/c1-10(2)9-11(17)14(20)18-7-3-5-12(18)15(21)19-8-4-6-13(19)16(22)23/h10-13H,3-9,17H2,1-2H3,(H,22,23)/t11-,12-,13-/m0/s1

InChIKey=DPURXCQCHSQPAN-AVGNSLFASA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides, the BRENDA database



Database reference:
AHTPDB: ID 1164, 1633, 3006, 3389, 3593, 3733, 4090, 4792, 5110, 5233, 5605, 5758, 6374

BioPepDB: OD 3391

BIOPEP-UWM database of bioactive peptides: ID

BRENDA: Ligand Leu-Pro-Pro

CAS: Registry No 121305-26-8

ChEBI: ID 159471

DFBP: ID DFBPACEI0495

EPAComPtox: ID DTXSID40153221

EROP-Moscow: ID E25007, E09255

Metabolomics Workbench: ID 83350

PlantPepDB: ID PPepDB_2925

PubChem: CID 3078466

SATPdb: ID satpdb18241

ZINC: ID ZINC000033901017