BIOPEP-UWM: Report

ID 3480
Name ACE-inhibitor (beta-casein, fr. 177-183)
sequence
AVPYPQR
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
7
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 829.9404 Monoisotopic mass 829.4433
IC50 :
15.00 µM


Bibliographic data:
Authors
Maruyama S, Nakagomi K, Tomizuka M, Suzuki H.
Title
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. II. Isolation and bradykinin potentiating activity on the uterus and the ileum of rats. Agric. Biol. Chem., 49, 41405-1409, 1985
Year Source
1985 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C38H59N11O10/c1-20(2)30(47-31(52)21(3)39)36(57)49-18-6-9-28(49)34(55)46-26(19-22-10-12-23(50)13-11-22)35(56)48-17-5-8-27(48)33(54)44-24(14-15-29(40)51)32(53)45-25(37(58)59)7-4-16-43-38(41)42/h10-13,20-21,24-28,30,50H,4-9,14-19,39H2,1-3H3,(H2,40,51)(H,44,54)(H,45,53)(H,46,55)(H,47,52)(H,58,59)(H4,41,42,43)/t21-,24-,25-,26-,27-,28-,30-/m0/s1

InChIKey=GIQZFLZPSASIEJ-YYNHRMGXSA-N


Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10248)
Iron chelating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10079); the PubChem database
Lipoxygenase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 7875)

Predicted antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 221)


Database reference:
AHTPDB: ID 1126, 1657, 1732, 3393, 3604, 3612, 4067, 4144, 4269, 5031, 5558, 5844, 5902, 6400

BioPepDB: ID biopep00091

BIOPEP-UWM database of bioactive peptides: ID 7875; 10079; 10248

BIOPEP-UWM Virtual database: ID 221

ChemSpider: ID 58809163

DFBP: ID DFBPACEI0272; DFBPANOX0126; DFBPANTH0164; DFBPMUFU0084

EROP-Moscow: ID E07426

FeptideDB: ID 3480; 7875

FermFooDB: ID FMDB16; FMDB1747; FMDB1748; FMDB1749; FMDB1750

MBPDB: Peptide AVPYPQR

PubChem: CID 14054420

SATPdb: ID satpdb12575