BIOPEP-UWM: Report
ID | 3489 |
Name | ACE inhibitor from sake lees |
sequence |
Function: | |||
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) | |||
Number of residues | 2 |
Activity code | ah |
Activity : | ACE inhibitor |
|||
Chemical mass | 321.3739 | Monoisotopic mass | 321.1796 | |
IC50 : | 93.00 µM |
Bibliographic data: | |
Authors | |
Saito Y., Wanezaki K., Kawato A., Imayasu S. | |
Title | |
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58(10), 1767-1771 (1994) | |
Year | Source |
1994 | Journal |
Additional information: |
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C15H23N5O3/c16-11(7-4-8-19-15(17)18)13(21)20-12(14(22)23)9-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,20,21)(H,22,23)(H4,17,18,19)/t11-,12-/m0/s1 InChIKey: PQBHGSGQZSOLIR-RYUDHWBXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001 Another value of peptide IC50(EC50)=230 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of UBR protein in rabbit reticulocyte lysates according to the PubChem database Inhibitor of dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9490); the BRENDA database Inhibitor of leucyltransferase (EC 2.3.2.6) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 13) Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 62) |
Database reference: |
ACToR: ID 2047-13-4 AHTPDB: ID 1184; 1251; 1370; 1505; 1666; 1921; 3202; 3793; 4019; 4110; 4242; 4439; 4499; 4688; 4961; 4962; 5425; 5450; 5567; 5620; 5860; 6155; 6408 BindingDB: ID 50407425 BIOPEP-UWM database of bioactive peptides: ID 9490 BIOPEP-UWM database of sensory peptides and amino acids: ID 13 BIOPEP-UWM Virtual database: ID 62 BRENDA: Ligand Arg-Phe ChEBI: ID 73818 ChEMBL: ID CHEMBL92255 ChemIDPlus: ID 2047-13-4 ChemSpider: ID 133060 EROP-Moscow: ID E00282 FeptideDB: ID 3489 J-Global: ID 200907001510653641 Metabolights: ID MTBLC73818 Nikkaji: ID J80.373A PubChem: CID 150964 SATPdb: ID satpdb13865 SureChEMBL: ID SCHEMBL1737558 ZINC: ID ZINC02384822 |