BIOPEP-UWM: Report

ID 3492
Name ACE inhibitor from sake
sequence
VY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 280.3188 Monoisotopic mass 280.1418
EC50 :
7.10 µM


Bibliographic data:
Authors
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Title
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58 (10), 1767-1771 (1994)
Year Source
1994 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

InChI=1S/C14H20N2O4/c1-8(2)12(15)13(18)16-11(14(19)20)7-9-3-5-10(17)6-4-9/h3-6,8,11-12,17H,7,15H2,1-2H3,(H,16,18)(H,19,20)/t11-,12-/m0/s1

InChIKey: VEYJKJORLPYVLO-RYUDHWBXSA-N


nformation concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Another measured value of peptide IC50(EC50)=26 uM

Loponen J., 2004, Angiotensin converting enzyme inhibitory peptides in Finnish cereals: a database survey. Agric. Food Sci., 13, 39-45.

Found also in wheat milling by-products:

Nogata Y., Nagamine T., Yanaka M., Ohta H., 2009, Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622;

found in potato protein hydrolysates

Cheng Y., Chen J., Xiong Y. L., 2010, Chromatographic separation and tandem MS identification of active peptides in potato protein hydrolysate that inhibit autoxidation of soybean oil-in-water emulsions. J. Agric. Food Chem., 58, 8825-8832;

found in amaranth protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8929)
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8224)
Inhibitor of Tripeptidyl peptidase 2 (TPP 2) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database; the ChEMBL database
Inhibitor of Dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9509); the BRENDA database

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids


Database reference:
AHTPDB: ID 1092; 1111; 1202; 1286; 1401; 1406; 1437; 1439; 1449; 1459; 1461; 1498; 1669; 1854; 1917; 1933; 2026; 2733; 2780; 2935; 2989; 3065; 3167; 3394; 3590; 3594; 3771; 3784; 4050; 4125; 4231; 4241; 4252; 4447; 4456; 4490; 4661; 4945; 4946; 5179; 5451; 5570; 5633; 6151; 6265; 6267; 6281; 6411; 6881

BindingDB: ID 50169147

BioPepDB: ID biopep01501

BIOPEP-UWM database of bioactive peptides: ID 8224; 8929; 9509

BIOPEP-UWM database of sensory peptides and amino acids: ID 103

BRENDA: Ligand Val-Tyr

ChEBI: ID 73703

ChEMBL: ID CHEMBL90069

ChemSpider: ID 5373134

EROP-Moscow database: ID E09051

J-GLOBAL: ID 200907095117777910

MBPDB: Peptide VY

Metabolights: ID MTBLC73703

Nikkaji: ID J149.639E

PubChem: ID 7009554

SATPdb: ID satpdb21554

SDBS: ID SDBS-4359

SureChEMBL: ID SCHEMBL4273366

ZINC: ID ZINC000002384776