BIOPEP-UWM: Report

ID 3494
Name ACE inhibitor from sake
sequence
HY
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 318.3271 Monoisotopic mass 318.1324
IC50 :
26.10 µM


Bibliographic data:
Authors
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Title
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58 (10), 1767-1771 (1994)
Year Source
1994 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O

InChI=1S/C15H18N4O4/c16-12(6-10-7-17-8-18-10)14(21)19-13(15(22)23)5-9-1-3-11(20)4-2-9/h1-4,7-8,12-13,20H,5-6,16H2,(H,17,18)(H,19,21)(H,22,23)/t12-,13-/m0/s1

InChIKey=HTOOKGDPMXSJSY-STQMWFEESA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found in amaranth (Amarantus hypochondriacus) protein hydrolysate:

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8799)
Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9869)


Database reference:
AHTPDB: ID 1144, 1369, 1916, 3203, 3498, 3943, 4077, 4240, 4734, 4960, 5154, 5593, 6150, 6413

BindingDB: ID 50049710

BioPepDB: ID biopep00478

BIOPEP-UWM database of bioactive peptides: ID 8799; 9869

BRENDA: Ligand His-Tyr

ChEBI: ID 74059

ChEMBL: ID CHEMBL3321987

ChemSpider: ID 449881

EChA: ID 807-648-0

EROP-Moscow: ID E09050

FeptideDB: ID 3494; 8799

FooDB: ID FDB111926

HMDB: ID HMDB0028897

J-GLOBAL: ID 200907091898175001

Metabolights: ID MTBLC74059

Nikkaji: ID J151.044D

PlantPepDB: ID PPepDB_2914

PubChem: CID 515713

SATPdb: ID satpdb10080

SureChEMBL: ID SCHEMBL1985387

ZINC: ID ZINC000001589278