BIOPEP-UWM: Report

ID 3502
Name ACE inhibitor
sequence
FP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
2
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 262.3036 Monoisotopic mass 262.1313
IC50 :
315.00 µM


Bibliographic data:
Authors
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Title
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81, 3131-3138, 1998
Year Source
1998 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C14H18N2O3/c15-11(9-10-5-2-1-3-6-10)13(17)16-8-4-7-12(16)14(18)19/h1-3,5-6,11-12H,4,7-9,15H2,(H,18,19)/t11-,12-/m0/s1

InChIKey=WEQJQNWXCSUVMA-RYUDHWBXSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Found in amaranth (Amarantus hypochondriacus) proteins:
Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8506); the BRENDA database; the EROP-Moscow database
Antifungal peptide according to the EROP-Moscow database
Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids; the EROP-Moscow database


Database reference:
AHTPDB: ID 1135; 1334; 1366; 1664; 1743; 2580; 3181; 3204; 3396; 3556; 3596; 3878; 3909; 4071; 4161; 4728; 4949; 5147; 5417; 5565; 5585; 5702; 5948; 6421; 6865

BIOPEP-UWM database of bioactive peptides: ID 3502; 8506

BIOPEP-UWM database of sensory peptides and amino acids; ID 45

BRENDA: Ligand Phe-Pro

CAS: ID 7669-65-0

ChEBI: ID 74750

ChEMBL: ID CHEMBL1807686

ChemSpider ID: 5383590

EROP-Moscow: ID E04808; E01602; E03693; E09206

HMDB: ID HMDB0011177

Metabolomics Workbench: ID 78930

Nikkaji: ID J661.079J

PubChem: CID 7020641

SureChEMBL: ID SCHEMBL3726264

ZINC: ID ZINC02392313