BIOPEP-UWM: Report
| ID | 3505 |
| Name | ACE inhibitor (beta-CN fr.59-61) |
| sequence |
| Function: | |||
| Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) | |||
| Number of residues | 3 |
Activity code | ah |
| Activity : | ACE inhibitor |
|||
| Chemical mass | 377.4337 | Monoisotopic mass | 377.1944 | |
| EC50 : | 288.00 µM |
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| Bibliographic data: | |
| Authors | |
| Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T. | |
| Title | |
| Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81(12), 3131-3138 (1998) | |
| Year | Source |
| 1998 | Journal |
| Additional information: |
| BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O)C(C)C InChI=1S/C19H27N3O5/c1-11(2)16(20)17(24)21-14(10-12-5-7-13(23)8-6-12)18(25)22-9-3-4-15(22)19(26)27/h5-8,11,14-16,23H,3-4,9-10,20H2,1-2H3,(H,21,24)(H,26,27)/t14-,15-,16-/m0/s1 InChIKey: PMKQKNBISAOSRI-JYJNAYRXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001 Another value of peptide IC50(EC50)=44 (from Meisel H., Walsh D. J., Murray B., FitzGerald R. J. [2006]. ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315). Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Neuropeptide according to ChEMBL database; EROP-Moscow database Bitter peptide according to BIOPEP database of sensory peptides and amino acids |
| Database reference: |
| AHTPDB: ID 1203; 1589; 1726; 2260; 2581; 3399; 3759; 4126; 4157; 4596; 4852; 4968; 5268; 5510; 5634; 5908; 5949; 6424; 6866 BIOPEP database of sensory peptides and amino acids: ID 72 ChEMBL: ID CHEMBL389820 ChemSpider: ID 10077308 EROP-Moscow: ID E09270 PubChem: ID 11902985 ZINC: ID ZINC04899808 |