BIOPEP-UWM: Report

ID 3518
Name ACE inhibitor
sequence
VAA

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 259.3013 Monoisotopic mass 259.1527
EC50 :
13.00 µM



Bibliographic data:
Authors
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.
Title
Structure and activity of angiotensin-converting enzyme inhibitors in alpha-zein hydrolysate. Agric. Biol. Chem., 55(5), 1313-1318 (1991)
Year Source
1991 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(NC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(N)C(C)C)C(O)=O

InChI=1S/C11H21N3O4/c1-5(2)8(12)10(16)13-6(3)9(15)14-7(4)11(17)18/h5-8H,12H2,1-4H3,(H,13,16)(H,14,15)(H,17,18)/t6-,7-,8-/m0/s1

InChIKey=IJBTVYLICXHDRI-FXQIFTODSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: XM02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111



Database reference: