BIOPEP-UWM: Report

ID 3524
Name ACE inhibitor (from bovine beta-CN)
sequence
VPP
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 311.3757 Monoisotopic mass 311.1839
IC50 :
9.00 µM


Bibliographic data:
Authors
Nakamura Y., Yamamoto N., Sakai K., Yamazaki S., Takano T.
Title
Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78, 777-783, 1995
Year Source
1995 Journal


Additional information:

BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C15H25N3O4/c1-9(2)12(16)14(20)17-7-3-5-10(17)13(19)18-8-4-6-11(18)15(21)22/h9-12H,3-8,16H2,1-2H3,(H,21,22)/t10-,11-,12-/m0/s1

InChIKey=DOFAQXCYFQKSHT-SRVKXCTJSA-N


Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001

Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Review concerning the peptide:
Li S., Bu T., Zheng J., Liu L., He G., Wu J., 2019, Preparation, bioavailability, and mechanism of emerging activities of Ile-Pro-Pro and Val-Pro-Pro. Compr. Rev. Food Sci. Food Saf., 18, 1097-1110


Antiinflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9538), the MBPDB database
Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BRENDA database


Database reference:
AHTPDB: ID 1200, 1275, 1583, 1671, 1711, 2009, 2244, 2740, 2971, 3205, 3403, 3589, 3628, 3735, 3774, 4043, 4122, 4178, 4799, 4963, 4964, 5125, 5262, 5515, 5572, 5629, 6092, 6442

BindingDB: ID 50169128

BioPepDB: ID biopep01435

BIOPEP-UWM database of bioactive peptides: ID 9538

BRENDA: Ligand Val-Pro-Pro

ChEBI: ID 73696

ChEMBL: ID CHEMBL190414

ChemIdPlus: ID 58872-39-2

ChemSpider: ID 7993950

Drug Information Portal: ID 58872-39-2

EROP-Moscow: ID E07046

FDA SRS: ID 2U1R84870F

J-GLOBAL: ID 200907032217042614

MBPDB: Peptide VPP

Metabolights: ID MTBLC73696

Nikkaji: ID J667.338D

PubChem: CID 9818200

SATPdb: ID satpdb19459

SureChEMBL: ID SCHEMBL1644894

ZINC: ID ZINC000013646338